Publications des scientifiques de l'IRD

Clarkson C. S., Miles A., Harding N. J., Lucas E. R., Battey C. J., Amaya-Romero J. E., Kern A. D., Fontaine M. C., Donnelly M. J., Lawniczak M. K. N., Kwiatkowski D. P., Donnelly M. J., Ayala Diego, Besansky N. J., Burt A., Caputo B., della Torre A., Fontaine M. C., Godfray H. C. J., Hahn M. W., Kern A. D., Kwiatkowski D. P., Lawniczak M. K. N., Midega J., O'Loughlin S., Pinto J., Riehle M. M., Sharakhov I., Schrider D. R., Vernick K. D., Weetman D., Wilding C. S., White B. J., Troco A. D., Pinto J., Cano J., Diabate A., Burt A., Costantini Carlo, Rohatgi K. R., Besansky N. J., Constant E., Weetman D., Elissa N., Nwakanma D. C., Jawara M., Essandoh J., Coulibaly B., Riehle M. M., Vernick K. D., Dinis J., Midega J., Mbogo C., Bejon P., Le Goff Gilbert, Robert Vincent, Wilding C. S., Mawejje H. D., Donnelly M. J., Stalker J., Rockett K. A., Drury E., Mead D., Jeffreys A. E., Hubbart C., Rowlands K., Isaacs A. T., Jyothi D., Malangone C., Kamali M., The Anopheles gambiae 1000 Genomes Consortium. (2020). Genome variation and population structure among 1142 mosquitoes of the African malaria vector species Anopheles gambiae and Anopheles coluzzii. Genome Research, 30 (10), p. 1533-1546. ISSN 1088-9051.

Titre du document
Genome variation and population structure among 1142 mosquitoes of the African malaria vector species Anopheles gambiae and Anopheles coluzzii
Année de publication
2020
Type de document
Article référencé dans le Web of Science WOS:000577121300013
Auteurs
Clarkson C. S., Miles A., Harding N. J., Lucas E. R., Battey C. J., Amaya-Romero J. E., Kern A. D., Fontaine M. C., Donnelly M. J., Lawniczak M. K. N., Kwiatkowski D. P., Donnelly M. J., Ayala Diego, Besansky N. J., Burt A., Caputo B., della Torre A., Fontaine M. C., Godfray H. C. J., Hahn M. W., Kern A. D., Kwiatkowski D. P., Lawniczak M. K. N., Midega J., O'Loughlin S., Pinto J., Riehle M. M., Sharakhov I., Schrider D. R., Vernick K. D., Weetman D., Wilding C. S., White B. J., Troco A. D., Pinto J., Cano J., Diabate A., Burt A., Costantini Carlo, Rohatgi K. R., Besansky N. J., Constant E., Weetman D., Elissa N., Nwakanma D. C., Jawara M., Essandoh J., Coulibaly B., Riehle M. M., Vernick K. D., Dinis J., Midega J., Mbogo C., Bejon P., Le Goff Gilbert, Robert Vincent, Wilding C. S., Mawejje H. D., Donnelly M. J., Stalker J., Rockett K. A., Drury E., Mead D., Jeffreys A. E., Hubbart C., Rowlands K., Isaacs A. T., Jyothi D., Malangone C., Kamali M., The Anopheles gambiae 1000 Genomes Consortium
Source
Genome Research, 2020, 30 (10), p. 1533-1546 ISSN 1088-9051
Mosquito control remains a central pillar of efforts to reduce malaria burden in sub-Saharan Africa. However, insecticide resistance is entrenched in malaria vector populations, and countries with a high malaria burden face a daunting challenge to sustain malaria control with a limited set of surveillance and intervention tools. Here we report on the second phase of a project to build an open resource of high-quality data on genome variation among natural populations of the major African malaria vector species Anopheles gambiae and Anopheles coluzzii. We analyzed whole genomes of 1142 individual mosquitoes sampled from the wild in 13 African countries, as well as a further 234 individuals comprising parents and progeny of 11 laboratory crosses. The data resource includes high-confidence single-nucleotide polymorphism (SNP) calls at 57 million variable sites, genome-wide copy number variation (CNV) calls, and haplotypes phased at biallelic SNPs. We use these data to analyze genetic population structure and characterize genetic diversity within and between populations. We illustrate the utility of these data by investigating species differences in isolation by distance, genetic variation within proposed gene drive target sequences, and patterns of resistance to pyrethroid insecticides. This data resource provides a foundation for developing new operational systems for molecular surveillance and for accelerating research and development of new vector control tools. It also provides a unique resource for the study of population genomics and evolutionary biology in eukaryotic species with high levels of genetic diversity under strong anthropogenic evolutionary pressures.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
AFRIQUE SUBSAHARIENNE ; BURKINA FASO ; GHANA ; COTE D'IVOIRE ; BURKINA FASO ; GUINEE ; CAMEROUN ; OUGANDA ; GUINEE BISSAU ; GAMBIE ; ANGOLA ; GABON ; KENYA ; MAYOTTE
Localisation
Fonds IRD [F B010079820]
Identifiant IRD
fdi:010079820
Contact