@article{fdi:010079820,
  title = {{G}enome variation and population structure among 1142 mosquitoes of the {A}frican malaria vector species {A}nopheles gambiae and {A}nopheles coluzzii},
  author = {{C}larkson, {C}. {S}. and {M}iles, {A}. and {H}arding, {N}. {J}. and {L}ucas, {E}. {R}. and {B}attey, {C}. {J}. and {A}maya-{R}omero, {J}. {E}. and {K}ern, {A}. {D}. and {F}ontaine, {M}. {C}. and {D}onnelly, {M}. {J}. and {L}awniczak, {M}. {K}. {N}. and {K}wiatkowski, {D}. {P}. and {D}onnelly, {M}. {J}. and {A}yala, {D}iego and {B}esansky, {N}. {J}. and {B}urt, {A}. and {C}aputo, {B}. and della {T}orre, {A}. and {F}ontaine, {M}. {C}. and {G}odfray, {H}. {C}. {J}. and {H}ahn, {M}. {W}. and {K}ern, {A}. {D}. and {K}wiatkowski, {D}. {P}. and {L}awniczak, {M}. {K}. {N}. and {M}idega, {J}. and {O}'{L}oughlin, {S}. and {P}into, {J}. and {R}iehle, {M}. {M}. and {S}harakhov, {I}. and {S}chrider, {D}. {R}. and {V}ernick, {K}. {D}. and {W}eetman, {D}. and {W}ilding, {C}. {S}. and {W}hite, {B}. {J}. and {T}roco, {A}. {D}. and {P}into, {J}. and {C}ano, {J}. and {D}iabate, {A}. and {B}urt, {A}. and {C}ostantini, {C}arlo and {R}ohatgi, {K}. {R}. and {B}esansky, {N}. {J}. and {C}onstant, {E}. and {W}eetman, {D}. and {E}lissa, {N}. and {N}wakanma, {D}. {C}. and {J}awara, {M}. and {E}ssandoh, {J}. and {C}oulibaly, {B}. and {R}iehle, {M}. {M}. and {V}ernick, {K}. {D}. and {D}inis, {J}. and {M}idega, {J}. and {M}bogo, {C}. and {B}ejon, {P}. and {L}e {G}off, {G}ilbert and {R}obert, {V}incent and {W}ilding, {C}. {S}. and {M}awejje, {H}. {D}. and {D}onnelly, {M}. {J}. and {S}talker, {J}. and {R}ockett, {K}. {A}. and {D}rury, {E}. and {M}ead, {D}. and {J}effreys, {A}. {E}. and {H}ubbart, {C}. and {R}owlands, {K}. and {I}saacs, {A}. {T}. and {J}yothi, {D}. and {M}alangone, {C}. and {K}amali, {M}. and {T}he {A}nopheles gambiae 1000 {G}enomes {C}onsortium},
  editor = {},
  language = {{ENG}},
  abstract = {{M}osquito control remains a central pillar of efforts to reduce malaria burden in sub-{S}aharan {A}frica. {H}owever, insecticide resistance is entrenched in malaria vector populations, and countries with a high malaria burden face a daunting challenge to sustain malaria control with a limited set of surveillance and intervention tools. {H}ere we report on the second phase of a project to build an open resource of high-quality data on genome variation among natural populations of the major {A}frican malaria vector species {A}nopheles gambiae and {A}nopheles coluzzii. {W}e analyzed whole genomes of 1142 individual mosquitoes sampled from the wild in 13 {A}frican countries, as well as a further 234 individuals comprising parents and progeny of 11 laboratory crosses. {T}he data resource includes high-confidence single-nucleotide polymorphism ({SNP}) calls at 57 million variable sites, genome-wide copy number variation ({CNV}) calls, and haplotypes phased at biallelic {SNP}s. {W}e use these data to analyze genetic population structure and characterize genetic diversity within and between populations. {W}e illustrate the utility of these data by investigating species differences in isolation by distance, genetic variation within proposed gene drive target sequences, and patterns of resistance to pyrethroid insecticides. {T}his data resource provides a foundation for developing new operational systems for molecular surveillance and for accelerating research and development of new vector control tools. {I}t also provides a unique resource for the study of population genomics and evolutionary biology in eukaryotic species with high levels of genetic diversity under strong anthropogenic evolutionary pressures.},
  keywords = {{AFRIQUE} {SUBSAHARIENNE} ; {BURKINA} {FASO} ; {GHANA} ; {COTE} {D}'{IVOIRE} ; {BURKINA} {FASO} ; {GUINEE} ; {CAMEROUN} ; {OUGANDA} ; {GUINEE} {BISSAU} ; {GAMBIE} ; {ANGOLA} ; {GABON} ; {KENYA} ; {MAYOTTE}},
  booktitle = {},
  journal = {{G}enome {R}esearch},
  volume = {30},
  numero = {10},
  pages = {1533--1546},
  ISSN = {1088-9051},
  year = {2020},
  DOI = {10.1101/gr.262790.120},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079820},
}