Publications des scientifiques de l'IRD

Rose N. H., Sylla M., Badolo A., Lutomiah J., Ayala Diego, Aribodor O. B., Ibe N., Akorli J., Otoo S., Mutebi J. P., Kriete A. L., Ewing E. G., Sang R., Gloria-Soria A., Powell J. R., Baker R. E., White B. J., Crawford J. E., McBride C. S. (2020). Climate and urbanization drive mosquito preference for humans. Current Biology, 30 (18), p. 3570-3579 + 6 p. ISSN 0960-9822.

Titre du document
Climate and urbanization drive mosquito preference for humans
Année de publication
2020
Type de document
Article référencé dans le Web of Science WOS:000574974100001
Auteurs
Rose N. H., Sylla M., Badolo A., Lutomiah J., Ayala Diego, Aribodor O. B., Ibe N., Akorli J., Otoo S., Mutebi J. P., Kriete A. L., Ewing E. G., Sang R., Gloria-Soria A., Powell J. R., Baker R. E., White B. J., Crawford J. E., McBride C. S.
Source
Current Biology, 2020, 30 (18), p. 3570-3579 + 6 p. ISSN 0960-9822
The majority of mosquito-borne illness is spread by a few mosquito species that have evolved to specialize in biting humans, yet the precise causes of this behavioral shift are poorly understood. We address this gap in the arboviral vector Aedes aegypti. We first collect and characterize the behavior of mosquitoes from 27 sites scattered across the species' ancestral range in sub-Saharan Africa, revealing previously unrecognized variation in preference for human versus animal odor We then use modeling to show that over 80% of this variation can be predicted by two ecological factors-dry season intensity and human population density. Finally, we integrate this information with whole-genome sequence data from 375 individual mosquitoes to identify a single underlying ancestry component linked to human preference. Genetic changes associated with human specialist ancestry were concentrated in a few chromosomal regions. Our findings suggest that human-biting in this important disease vector originally evolved as a by-product of breeding in human-stored water in areas where doing so provided the only means to survive the long, hot dry season. Our model also predicts that the rapid urbanization currently taking place in Africa will drive further mosquito evolution, causing a shift toward human-biting in many large cities by 2050.
Plan de classement
Sciences du milieu [021] ; Entomologie médicale / Parasitologie / Virologie [052] ; Urbanisation et sociétés urbaines [102]
Description Géographique
AFRIQUE SUBSAHARIENNE
Localisation
Fonds IRD [F B010079771]
Identifiant IRD
fdi:010079771
Contact