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Manasfi R., Chiron Serge, Montemurro N., Perez S., Brienza Monica. (2020). Biodegradation of fluoroquinolone antibiotics and the climbazole fungicide by Trichoderma species. Environmental Science and Pollution Research, [Early access], [11 p.]. ISSN 0944-1344

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Lien direct chez l'éditeur doi:10.1007/s11356-020-08442-8

Biodegradation of fluoroquinolone antibiotics and the climbazole fungicide by Trichoderma species
Année de publication2020
Type de documentArticle référencé dans le Web of Science WOS:000528988900003
AuteursManasfi R., Chiron Serge, Montemurro N., Perez S., Brienza Monica.
SourceEnvironmental Science and Pollution Research, 2020, [Early access], p. [11 p.]. p. [11 p.] ISSN 0944-1344
RésuméFilamentous fungi Trichoderma have been able to efficiently degrade fluoroquinolone antibiotics namely ciprofloxacin (CIP) and ofloxacin (OFL) as well as the fungicide climbazole (CLB) that are persistent in conventional activated sludge processes. All targeted compounds were biotransformed by whole cells of Trichoderma spp., exactly T. harzanium and T. asperellum, and biosorption played a limited role in their elimination. However, contrasting results were obtained with the two strains. T. asperellum was more efficient against CIP, with a 81% degradation rate in 13 days of incubation, while T. harzianum was more efficient against CLB, with a 91% degradation rate. While in the case of OFL, both strains showed same efficiency with degradation rate around 40%. Adding a cytochrome P450 enzyme inhibitor hardly resulted in the modification of degradation kinetics supporting the implication of extracellular enzymes in chemical biotransformation. Transformation products were identified by liquid chromatography-high resolution-mass spectrometry and transformation pathways were proposed. Biotransformation of selected compounds included hydroxylation, oxidation/reduction and N- and O-dealkylation reactions, similarly to those reported with white rot fungi. CIP underwent transformations at the piperazinyl ring through oxidation and conjugation reactions, while OFL mainly underwent hydroxylation processes and CLB carbonyl reduction into alcohol. Consequently, Trichoderma spp. likely possess a machinery of unspecific enzymes, which makes their application in removal of pharmaceutical and personal care products attractive.
Plan de classementPollution [038] ; Biotechnologies [084] ; Sciences fondamentales / Techniques d'analyse et de recherche [020]
LocalisationFonds IRD [F B010079031]
Identifiant IRDfdi:010079031
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010079031

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