Sigh S., Lauritzen L., Wieringa Franck, Laillou A., Chamnan C., Angkeabos N., Moniboth D., Berger Jacques, Stark K. D., Roos N. (2020). Whole-blood PUFA and associations with markers of nutritional and health status in acutely malnourished children in Cambodia. Public Health Nutrition, 23 (6), p. 974-986. ISSN 1368-9800.
Titre du document
Whole-blood PUFA and associations with markers of nutritional and health status in acutely malnourished children in Cambodia
Année de publication
2020
Auteurs
Sigh S., Lauritzen L., Wieringa Franck, Laillou A., Chamnan C., Angkeabos N., Moniboth D., Berger Jacques, Stark K. D., Roos N.
Source
Public Health Nutrition, 2020,
23 (6), p. 974-986 ISSN 1368-9800
Objective: To measure fatty acid composition, particularly whole-blood PUFA content, in acutely malnourished children and identify associations with markers of nutritional and health status. Design: PUFA were assessed in dried blood spots obtained from a cross-sectional study. Nutritional and health status were assessed by anthropometry, haemoglobinopathies, inflammation and blood counts. Setting: Cambodia. Participants: The study was conducted with 174 children aged 0 center dot 5-18 years with acute malnutrition. Results: Among total fatty acids (FA), the relative percentage of total PUFA was 20 % FA, with 14 % of the children having very low PUFA (mead acid (MA):arachidonic acid (AA) >0 center dot 02, n-6 docosapentaenoic acid:DHA >0 center dot 2 and total n-6:n-3 PUFA >10 center dot 5). Wasting was not associated with any PUFA. Stunting and low height were consistently positively associated with total PUFA and positively with n-6 PUFA. Height was positively associated with n-3 long-chain PUFA (LCPUFA). The presence of haemoglobinopathies or inflammation was positively associated with MA:AA, but not total PUFA. Elevated blood platelet counts were positively correlated with linoleic acid and appeared to be influenced by anaemia (P = 0 center dot 010) and inflammation (P = 0 center dot 002). Monocyte counts were high during inflammation (P = 0 center dot 052) and correlated positively with n-6 LCPUFA and n-3 LCPUFA. Conclusions: Children with acute malnutrition or stunting had low PUFA, while elevated platelets and monocytes were associated with high PUFA. In acutely malnourished children, inflammation could lead to elevated blood cell counts resulting in increased whole-blood PUFA which does not reflect dietary intake or nutritional status.
Plan de classement
Santé : généralités [050]
;
Nutrition, alimentation [054]
Description Géographique
CAMBODGE
Localisation
Fonds IRD [F B010078958]
Identifiant IRD
fdi:010078958
