@article{fdi:010078958,
  title = {{W}hole-blood {PUFA} and associations with markers of nutritional and health status in acutely malnourished children in {C}ambodia},
  author = {{S}igh, {S}. and {L}auritzen, {L}. and {W}ieringa, {F}ranck and {L}aillou, {A}. and {C}hamnan, {C}. and {A}ngkeabos, {N}. and {M}oniboth, {D}. and {B}erger, {J}acques and {S}tark, {K}. {D}. and {R}oos, {N}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective: {T}o measure fatty acid composition, particularly whole-blood {PUFA} content, in acutely malnourished children and identify associations with markers of nutritional and health status. {D}esign: {PUFA} were assessed in dried blood spots obtained from a cross-sectional study. {N}utritional and health status were assessed by anthropometry, haemoglobinopathies, inflammation and blood counts. {S}etting: {C}ambodia. {P}articipants: {T}he study was conducted with 174 children aged 0 center dot 5-18 years with acute malnutrition. {R}esults: {A}mong total fatty acids ({FA}), the relative percentage of total {PUFA} was 20 % {FA}, with 14 % of the children having very low {PUFA} (mead acid ({MA}):arachidonic acid ({AA}) >0 center dot 02, n-6 docosapentaenoic acid:{DHA} >0 center dot 2 and total n-6:n-3 {PUFA} >10 center dot 5). {W}asting was not associated with any {PUFA}. {S}tunting and low height were consistently positively associated with total {PUFA} and positively with n-6 {PUFA}. {H}eight was positively associated with n-3 long-chain {PUFA} ({LCPUFA}). {T}he presence of haemoglobinopathies or inflammation was positively associated with {MA}:{AA}, but not total {PUFA}. {E}levated blood platelet counts were positively correlated with linoleic acid and appeared to be influenced by anaemia ({P} = 0 center dot 010) and inflammation ({P} = 0 center dot 002). {M}onocyte counts were high during inflammation ({P} = 0 center dot 052) and correlated positively with n-6 {LCPUFA} and n-3 {LCPUFA}. {C}onclusions: {C}hildren with acute malnutrition or stunting had low {PUFA}, while elevated platelets and monocytes were associated with high {PUFA}. {I}n acutely malnourished children, inflammation could lead to elevated blood cell counts resulting in increased whole-blood {PUFA} which does not reflect dietary intake or nutritional status.},
  keywords = {{PUFA} ; {B}lood cell counts ; {A}cutely malnourished children ; {N}utritional status ; {I}nflammation ; {CAMBODGE}},
  booktitle = {},
  journal = {{P}ublic {H}ealth {N}utrition},
  volume = {23},
  numero = {6},
  pages = {974--986},
  ISSN = {1368-9800},
  year = {2020},
  DOI = {10.1017/s1368980019003744},
  URL = {https://www.documentation.ird.fr/hor/fdi:010078958},
}