Mesquita I., Vergnes Baptiste. (2018). Alterations on cellular redox states upon infection and implications for host cell homeostasis. In :
Silvestre R. (ed.), Torrado E. (ed.). Metabolic interaction in Infection. Cham : Springer, p. 197-220. (Experientia Supplementum ; 109). ISBN 978-3-319-74932-7. ISSN 1664-431X.
Titre du document
Alterations on cellular redox states upon infection and implications for host cell homeostasis
Année de publication
2018
Type de document
Partie d'ouvrage
Auteurs
Mesquita I., Vergnes Baptiste
In
Silvestre R. (ed.), Torrado E. (ed.), Metabolic interaction in Infection
Source
Cham : Springer, 2018,
p. 197-220 (Experientia Supplementum ; 109). ISBN 978-3-319-74932-7 ISSN 1664-431X
The cofactors nicotinamide adenine dinucleotide (NAD+) and its phosphate
form, NADP+, are crucial molecules present in all living cells. The delicate balance
between the oxidized and reduced forms of these molecules is tightly regulated by
intracellular metabolism assuring the maintenance of homeostatic conditions, which
are essential for cell survival and proliferation. A recent cluster of data has highlighted
the importance of the intracellular NAD+/NADH and NADP+/NADPH ratios during
host–pathogen interactions, as fluctuations in the levels of these cofactors and in
precursors’ bioavailability may condition host response and, therefore, pathogen
persistence or elimination. Furthermore, an increasing interest has been given towards
how pathogens are capable of hijacking host cell proteins in their own advantage and,
consequently, alter cellular redox states and immune function. Here, we review the
basic principles behind biosynthesis and subcellular compartmentalization of NAD+
and NADP+, as well as the importance of these cofactors during infection, with a
special emphasis on pathogen-driven modulation of host NAD+/NADP+ levels and
contribution to the associated immune response.
