Mesquita I. auteur aut IRD Vergnes Baptiste auteur aut IRD text bookSection eng text/pdf born digital access The cofactors nicotinamide adenine dinucleotide (NAD+) and its phosphate form, NADP+, are crucial molecules present in all living cells. The delicate balance between the oxidized and reduced forms of these molecules is tightly regulated by intracellular metabolism assuring the maintenance of homeostatic conditions, which are essential for cell survival and proliferation. A recent cluster of data has highlighted the importance of the intracellular NAD+/NADH and NADP+/NADPH ratios during host–pathogen interactions, as fluctuations in the levels of these cofactors and in precursors’ bioavailability may condition host response and, therefore, pathogen persistence or elimination. Furthermore, an increasing interest has been given towards how pathogens are capable of hijacking host cell proteins in their own advantage and, consequently, alter cellular redox states and immune function. Here, we review the basic principles behind biosynthesis and subcellular compartmentalization of NAD+ and NADP+, as well as the importance of these cofactors during infection, with a special emphasis on pathogen-driven modulation of host NAD+/NADP+ levels and contribution to the associated immune response. specialized INFECTION RELATION HOTE PARASITE BIOCHIMIE HOMEOSTASIE IMMUNOLOGIE METABOLISME 052 020BIOCHI Silvestre R. ed. edt IRD Torrado E. ed. edt IRD 109 197-220 Cham Springer 2018 109 https://www.documentation.ird.fr/hor/fdi:010078404 10.1007/978-3-319-74932-7_4 978-3-319-74932-7 [F B010078404] https://www.documentation.ird.fr/hor/fdi:010078404 https://www.documentation.ird.fr/intranet/publi/depot/2020-06-26/010078404.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2020-06-22 2023-07-11 fdi:010078404 fre