Koyo C. S. B., Oyegue-Liabagui S. L., Mediannikov Oleg, Cortaredona Sébastien, Kouna L. C., Raoult D., Lekana-Douki J. B., Fenollar F. (2020). High circulation of malaria and low prevalence of bacteremia in febrile and afebrile children in Northeastern Gabon. American Journal of Tropical Medicine and Hygiene, 102 (1), p. 121-129. ISSN 0002-9637.
Titre du document
High circulation of malaria and low prevalence of bacteremia in febrile and afebrile children in Northeastern Gabon
Année de publication
2020
Auteurs
Koyo C. S. B., Oyegue-Liabagui S. L., Mediannikov Oleg, Cortaredona Sébastien, Kouna L. C., Raoult D., Lekana-Douki J. B., Fenollar F.
Source
American Journal of Tropical Medicine and Hygiene, 2020,
102 (1), p. 121-129 ISSN 0002-9637
The epidemiology of febrile illness etiologies is under-explored in resource-poor settings. Establishing a local repertory of microorganisms circulating in blood of febrile and afebrile people is important for physicians. Blood was collected from 428 febrile and 88 afebrile children in Makokou (Gabon) and analyzed using polymerase chain reaction. Plasmodium spp. were the pathogens, which were most detected in febrile children (69.6%; 298/428) and in afebrile children (31.8%; 28/88) (P < 0.0001). Plasmodium falciparum was the most prevalent species in both febrile and afebrile children (66.8% and 27.3%, respectively). No differences were observed between febrile and afebrile children for Plasmodium malariae and Plasmodium ovale (8.2% versus 10.2% and 3.3% versus 3.4%, respectively). Triple infection with P. falciparum, P. malariae, and P. ovale was also detected in 1% of febrile children (4/428). Filariasis due to Mansonella perstans was detected in 10 febrile patients (2.3%), whereas Loa loa was detected in both febrile and afebrile children (1.4% and 2.3%, respectively). Bacterial DNA was detected in only 4.4% (19/428) of febrile children, including 13 (68.4%) who were coinfected with at least one Plasmodium species. These were Haemophilus influenzae (1.6%, 7/428), Streptococcus pneumoniae and Staphylococcus aureus (1.2%, 5/428), and Rickettsia fells (0.9%, 4/428). Coxiella burnetii, Bartonella spp., Borrelia spp., Tropheryma whipplei, Anaplasma spp., Leptospira spp., Streptococcus pyogenes, and Salmonella spp. were not detected. This study also highlights the over-prescription and the overuse of antibiotics and antimalarials. Overall, malaria remains a major health problem in Makokou. Malaria control measures must be reconsidered in this region.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
GABON
Localisation
Fonds IRD [F B010077782]
Identifiant IRD
fdi:010077782
