@article{fdi:010077782,
  title = {{H}igh circulation of malaria and low prevalence of bacteremia in febrile and afebrile children in {N}ortheastern {G}abon},
  author = {{K}oyo, {C}. {S}. {B}. and {O}yegue-{L}iabagui, {S}. {L}. and {M}ediannikov, {O}leg and {C}ortaredona, {S}{\'e}bastien and {K}ouna, {L}. {C}. and {R}aoult, {D}. and {L}ekana-{D}ouki, {J}. {B}. and {F}enollar, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he epidemiology of febrile illness etiologies is under-explored in resource-poor settings. {E}stablishing a local repertory of microorganisms circulating in blood of febrile and afebrile people is important for physicians. {B}lood was collected from 428 febrile and 88 afebrile children in {M}akokou ({G}abon) and analyzed using polymerase chain reaction. {P}lasmodium spp. were the pathogens, which were most detected in febrile children (69.6%; 298/428) and in afebrile children (31.8%; 28/88) ({P} < 0.0001). {P}lasmodium falciparum was the most prevalent species in both febrile and afebrile children (66.8% and 27.3%, respectively). {N}o differences were observed between febrile and afebrile children for {P}lasmodium malariae and {P}lasmodium ovale (8.2% versus 10.2% and 3.3% versus 3.4%, respectively). {T}riple infection with {P}. falciparum, {P}. malariae, and {P}. ovale was also detected in 1% of febrile children (4/428). {F}ilariasis due to {M}ansonella perstans was detected in 10 febrile patients (2.3%), whereas {L}oa loa was detected in both febrile and afebrile children (1.4% and 2.3%, respectively). {B}acterial {DNA} was detected in only 4.4% (19/428) of febrile children, including 13 (68.4%) who were coinfected with at least one {P}lasmodium species. {T}hese were {H}aemophilus influenzae (1.6%, 7/428), {S}treptococcus pneumoniae and {S}taphylococcus aureus (1.2%, 5/428), and {R}ickettsia fells (0.9%, 4/428). {C}oxiella burnetii, {B}artonella spp., {B}orrelia spp., {T}ropheryma whipplei, {A}naplasma spp., {L}eptospira spp., {S}treptococcus pyogenes, and {S}almonella spp. were not detected. {T}his study also highlights the over-prescription and the overuse of antibiotics and antimalarials. {O}verall, malaria remains a major health problem in {M}akokou. {M}alaria control measures must be reconsidered in this region.},
  keywords = {{GABON}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {102},
  numero = {1},
  pages = {121--129},
  ISSN = {0002-9637},
  year = {2020},
  DOI = {10.4269/ajtmh.19-0368},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077782},
}