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Archary M., Zanoni B., Lallemant Marc, Suwannaprom P., Clarke D., Penazzato M. (2020). Acceptability and feasibility of using raltegravir oral granules for the treatment of neonates in a low-resource setting. Pediatric Infectious Disease Journal, 39 (1), 57-60. ISSN 0891-3668

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Lien direct chez l'éditeur doi:10.1097/inf.0000000000002539

Titre
Acceptability and feasibility of using raltegravir oral granules for the treatment of neonates in a low-resource setting
Année de publication2020
Type de documentArticle référencé dans le Web of Science WOS:000503803200016
AuteursArchary M., Zanoni B., Lallemant Marc, Suwannaprom P., Clarke D., Penazzato M.
SourcePediatric Infectious Disease Journal, 2020, 39 (1), p. 57-60. ISSN 0891-3668
RésuméBackground: Raltegravir granules for oral suspension, now recommended by World Health Organization for use in neonates with HIV infection, may be challenging for caregivers because of the multistep preparation required. Methods: We evaluated the acceptability and feasibility of preparing granules for oral suspension in a low-to-middle-income country setting. Thirty-four caregivers and 10 health-care workers were enrolled from an HIV clinic in Durban, South Africa. Health-care workers were provided with pictorial instruction booklet, demonstration kit and guidance on preparation of granules for oral suspension. The health-care workers then trained caregivers on the preparation of granules for oral suspension. Caregivers were evaluated during the preparation process and instructed to practice at home with a sample kit and return to the clinic for repeat evaluation 5-7 days later. Caregivers and health-care workers were interviewed and participated in a focus group discussion regarding their experiences. Results: The median age of the caregivers was 31 years (interquartile range: 9.7); 70% had received secondary-level education, 37% were employed. The median preparation time was 7.95 minutes (interquartile range: 5.08 minutes) and 7.48 minutes (3.55 minutes) at initial and repeated observation, respectively. Major errors were insufficient mixing time and incorrect suspension volume. The average number of errors between the 2 observation time points was significantly reduced at the repeat session (2.5 vs. 0.87, P = 0.023). Most participants found the preparation difficult at first but gained confidence over time. Conclusion: Despite the complexity involved in the preparation of the granules for oral suspension, with practice, this formulation was found to be acceptable and feasible to majority of participants in this low-resource setting. As a result, this formulation was included in the 2018 World Health Organization recommendations for first line in neonates living with HIV.
Plan de classementSanté : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Descr. géo.AFRIQUE DU SUD
LocalisationFonds IRD [F B010077488]
Identifiant IRDfdi:010077488
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010077488

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