@article{fdi:010077488,
  title = {{A}cceptability and feasibility of using raltegravir oral granules for the treatment of neonates in a low-resource setting},
  author = {{A}rchary, {M}. and {Z}anoni, {B}. and {L}allemant, {M}arc and {S}uwannaprom, {P}. and {C}larke, {D}. and {P}enazzato, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {R}altegravir granules for oral suspension, now recommended by {W}orld {H}ealth {O}rganization for use in neonates with {HIV} infection, may be challenging for caregivers because of the multistep preparation required. {M}ethods: {W}e evaluated the acceptability and feasibility of preparing granules for oral suspension in a low-to-middle-income country setting. {T}hirty-four caregivers and 10 health-care workers were enrolled from an {HIV} clinic in {D}urban, {S}outh {A}frica. {H}ealth-care workers were provided with pictorial instruction booklet, demonstration kit and guidance on preparation of granules for oral suspension. {T}he health-care workers then trained caregivers on the preparation of granules for oral suspension. {C}aregivers were evaluated during the preparation process and instructed to practice at home with a sample kit and return to the clinic for repeat evaluation 5-7 days later. {C}aregivers and health-care workers were interviewed and participated in a focus group discussion regarding their experiences. {R}esults: {T}he median age of the caregivers was 31 years (interquartile range: 9.7); 70% had received secondary-level education, 37% were employed. {T}he median preparation time was 7.95 minutes (interquartile range: 5.08 minutes) and 7.48 minutes (3.55 minutes) at initial and repeated observation, respectively. {M}ajor errors were insufficient mixing time and incorrect suspension volume. {T}he average number of errors between the 2 observation time points was significantly reduced at the repeat session (2.5 vs. 0.87, {P} = 0.023). {M}ost participants found the preparation difficult at first but gained confidence over time. {C}onclusion: {D}espite the complexity involved in the preparation of the granules for oral suspension, with practice, this formulation was found to be acceptable and feasible to majority of participants in this low-resource setting. {A}s a result, this formulation was included in the 2018 {W}orld {H}ealth {O}rganization recommendations for first line in neonates living with {HIV}.},
  keywords = {acceptability ; feasibility ; raltegravir granules ; neonatal treatment ; {AFRIQUE} {DU} {SUD}},
  booktitle = {},
  journal = {{P}ediatric {I}nfectious {D}isease {J}ournal},
  volume = {39},
  numero = {1},
  pages = {57--60},
  ISSN = {0891-3668},
  year = {2020},
  DOI = {10.1097/inf.0000000000002539},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077488},
}