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Quakyi I., Tornyigah B., Houze P., Kusi K. A., Coleman N., Escriou G., Laar A., Cot Michel, Fobil J., Asare G. Q., Deloron Philippe, Anang A. K., Cottrell Gilles, Ofori M. F., Tuikue Ndam Nicaise. (2019). High uptake of Intermittent Preventive Treatment of malaria in pregnancy is associated with improved birth weight among pregnant women in Ghana. Scientific Reports - Nature, 9, art. 19034 [8p.]. ISSN 2045-2322

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Lien direct chez l'éditeur doi:10.1038/s41598-019-55046-5

Titre
High uptake of Intermittent Preventive Treatment of malaria in pregnancy is associated with improved birth weight among pregnant women in Ghana
Année de publication2019
Type de documentArticle référencé dans le Web of Science WOS:000503075200002
AuteursQuakyi I., Tornyigah B., Houze P., Kusi K. A., Coleman N., Escriou G., Laar A., Cot Michel, Fobil J., Asare G. Q., Deloron Philippe, Anang A. K., Cottrell Gilles, Ofori M. F., Tuikue Ndam Nicaise.
SourceScientific Reports - Nature, 2019, 9, p. art. 19034 [8p.]. p. art. 19034 [8p.] ISSN 2045-2322
RésuméDespite the clinically proven advantages of intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP), utilisation has been low in many African countries. To increase uptake and achieve the desired effect, the World Health Organization revised the policy to a monthly administration. Assessing the coverage and impact of the revised policy on pregnancy and neonatal outcomes is, therefore, a necessity. A 2-parallel cross-sectional hospital-based study was carried out among pregnant women attending first antenatal care (ANC) and delivery. Maternal and cord blood samples were assayed for malaria parasites by quantitative PCR targeting both the 18S rDNA and the acidic terminal segment of Plasmodium falciparum var genes, and plasma SP levels were measured by liquid chromatography coupled to tandem mass spectrometry. Parasite prevalence was similar between the two study sites but decreased significantly between the first ANC (9% or 43%) and delivery (4% or 11%) based on the qPCR target. At delivery, 64.5% of women received >= 3 IPTp-SP dose, 15.5% received 2 doses and 6% had 1 dose. Taking >= 3 IPTp-SP doses was associated with an average birth weight increase of more than 0.165 kg. IPTp-SP uptake was associated with plasma SP level at delivery (OR= 32.3, p <= 0.005, 95% CI (13.3;78.4) for those that reported >= 3 IPTp-SP doses) while the same trend of improved birth weight was observed with high plasma SP levels. The new IPTp policy is well implemented and well utilised by women in the sites considered in this study and translates to the improved birth weight observed. This study confirms the interest and the clinical benefit expected from this policy change.
Plan de classementSanté : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Descr. géo.GHANA
LocalisationFonds IRD [F B010077479]
Identifiant IRDfdi:010077479
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010077479

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