@article{fdi:010077479,
  title = {{H}igh uptake of {I}ntermittent {P}reventive {T}reatment of malaria in pregnancy is associated with improved birth weight among pregnant women in {G}hana},
  author = {{Q}uakyi, {I}. and {T}ornyigah, {B}. and {H}ouze, {P}. and {K}usi, {K}. {A}. and {C}oleman, {N}. and {E}scriou, {G}. and {L}aar, {A}. and {C}ot, {M}ichel and {F}obil, {J}. and {A}sare, {G}. {Q}. and {D}eloron, {P}hilippe and {A}nang, {A}. {K}. and {C}ottrell, {G}illes and {O}fori, {M}. {F}. and {T}uikue {N}dam, {N}icaise},
  editor = {},
  language = {{ENG}},
  abstract = {{D}espite the clinically proven advantages of intermittent preventive treatment of malaria in pregnancy ({IPT}p) with sulfadoxine-pyrimethamine ({SP}), utilisation has been low in many {A}frican countries. {T}o increase uptake and achieve the desired effect, the {W}orld {H}ealth {O}rganization revised the policy to a monthly administration. {A}ssessing the coverage and impact of the revised policy on pregnancy and neonatal outcomes is, therefore, a necessity. {A} 2-parallel cross-sectional hospital-based study was carried out among pregnant women attending first antenatal care ({ANC}) and delivery. {M}aternal and cord blood samples were assayed for malaria parasites by quantitative {PCR} targeting both the 18{S} r{DNA} and the acidic terminal segment of {P}lasmodium falciparum var genes, and plasma {SP} levels were measured by liquid chromatography coupled to tandem mass spectrometry. {P}arasite prevalence was similar between the two study sites but decreased significantly between the first {ANC} (9% or 43%) and delivery (4% or 11%) based on the q{PCR} target. {A}t delivery, 64.5% of women received >= 3 {IPT}p-{SP} dose, 15.5% received 2 doses and 6% had 1 dose. {T}aking >= 3 {IPT}p-{SP} doses was associated with an average birth weight increase of more than 0.165 kg. {IPT}p-{SP} uptake was associated with plasma {SP} level at delivery ({OR}= 32.3, p <= 0.005, 95% {CI} (13.3;78.4) for those that reported >= 3 {IPT}p-{SP} doses) while the same trend of improved birth weight was observed with high plasma {SP} levels. {T}he new {IPT}p policy is well implemented and well utilised by women in the sites considered in this study and translates to the improved birth weight observed. {T}his study confirms the interest and the clinical benefit expected from this policy change.},
  keywords = {{GHANA}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {9},
  numero = {},
  pages = {art. 19034 [8p.]},
  ISSN = {2045-2322},
  year = {2019},
  DOI = {10.1038/s41598-019-55046-5},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077479},
}