Publications des scientifiques de l'IRD

Agbota G., Polman K., Wieringa Franck, Campos-Ponce M., Accrombessi M., Yovo E., Roucher C., Ezinmegnon S., Marcos J. Y., Vachot L., Tissieres P., Massougbodji A., Fievet Nadine, Cot Michel, Briand Valérie. (2019). Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life : a mother-child cohort in Benin. PLoS One, 14 (9), p. e0222864 [13 p.]. ISSN 1932-6203.

Titre du document
Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life : a mother-child cohort in Benin
Année de publication
2019
Type de document
Article référencé dans le Web of Science WOS:000498544800001
Auteurs
Agbota G., Polman K., Wieringa Franck, Campos-Ponce M., Accrombessi M., Yovo E., Roucher C., Ezinmegnon S., Marcos J. Y., Vachot L., Tissieres P., Massougbodji A., Fievet Nadine, Cot Michel, Briand Valérie
Source
PLoS One, 2019, 14 (9), p. e0222864 [13 p.] ISSN 1932-6203
Background Malaria and schistosomiasis represent two of the most prevalent and disabling parasitic infections in developing countries. Few studies have evaluated the effect of maternal schistosomiasis and malaria in the peri-conceptional period on infant's risk of infection. Methods In Benin, women were followed from the preconception period until delivery. Subsequently, their children were followed from birth to 3 months of age. Pre-pregnancy malaria, malaria in pregnancy (MiP)-determined monthly using a thick blood smear-and urinary schistosomiasis-determined once before pregnancy and once at delivery using urine filtration-were the main maternal exposures. Infant's febrile infection (fever with respiratory, gastrointestinal and/or cutaneous clinical signs anytime during follow-up) was the main outcome. In a secondary analysis, we checked the relation of malaria and schistosomiasis with infant's hemoglobin (Hb) concentration. Both effects were separately assessed using logistic/mixed linear regression models. Results The prevalence of MiP was 35.7% with 10.8% occurring during the 1st trimester, and the prevalence of schistosomiasis was 21.8%. From birth to 3 months, 25.3% of infants had at least one episode of febrile infection. In multivariate analysis, MiP, particularly malaria in the 1st trimester, was significantly associated with a higher risk of infant's febrile infection (aOR = 4.99 [1.1; 22.6], p = 0.03). In secondary results, pre-pregnancy malaria and schistosomiasis were significantly associated with a lower infant's Hb concentration during the first 3 months. Conclusion We evidenced the deleterious effect of maternal parasitic infections on infant's health. Our results argue in favor of the implementation of preventive strategies as early as in the periconception.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
BENIN
Localisation
Fonds IRD [F B010077367]
Identifiant IRD
fdi:010077367
Contact