@article{fdi:010077367,
  title = {{M}aternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life : a mother-child cohort in {B}enin},
  author = {{A}gbota, {G}. and {P}olman, {K}. and {W}ieringa, {F}ranck and {C}ampos-{P}once, {M}. and {A}ccrombessi, {M}. and {Y}ovo, {E}. and {R}oucher, {C}. and {E}zinmegnon, {S}. and {M}arcos, {J}. {Y}. and {V}achot, {L}. and {T}issieres, {P}. and {M}assougbodji, {A}. and {F}ievet, {N}adine and {C}ot, {M}ichel and {B}riand, {V}al{\'e}rie},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {M}alaria and schistosomiasis represent two of the most prevalent and disabling parasitic infections in developing countries. {F}ew studies have evaluated the effect of maternal schistosomiasis and malaria in the peri-conceptional period on infant's risk of infection. {M}ethods {I}n {B}enin, women were followed from the preconception period until delivery. {S}ubsequently, their children were followed from birth to 3 months of age. {P}re-pregnancy malaria, malaria in pregnancy ({M}i{P})-determined monthly using a thick blood smear-and urinary schistosomiasis-determined once before pregnancy and once at delivery using urine filtration-were the main maternal exposures. {I}nfant's febrile infection (fever with respiratory, gastrointestinal and/or cutaneous clinical signs anytime during follow-up) was the main outcome. {I}n a secondary analysis, we checked the relation of malaria and schistosomiasis with infant's hemoglobin ({H}b) concentration. {B}oth effects were separately assessed using logistic/mixed linear regression models. {R}esults {T}he prevalence of {M}i{P} was 35.7% with 10.8% occurring during the 1st trimester, and the prevalence of schistosomiasis was 21.8%. {F}rom birth to 3 months, 25.3% of infants had at least one episode of febrile infection. {I}n multivariate analysis, {M}i{P}, particularly malaria in the 1st trimester, was significantly associated with a higher risk of infant's febrile infection (a{OR} = 4.99 [1.1; 22.6], p = 0.03). {I}n secondary results, pre-pregnancy malaria and schistosomiasis were significantly associated with a lower infant's {H}b concentration during the first 3 months. {C}onclusion {W}e evidenced the deleterious effect of maternal parasitic infections on infant's health. {O}ur results argue in favor of the implementation of preventive strategies as early as in the periconception.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{PL}o{S} {O}ne},
  volume = {14},
  numero = {9},
  pages = {e0222864 [13 p.]},
  ISSN = {1932-6203},
  year = {2019},
  DOI = {10.1371/journal.pone.0222864},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077367},
}