Publications des scientifiques de l'IRD

Chhour M., Aubouy Agnès, Bourgeade-Delmas Sandra, Perio Pierre, Ternet-Fontebasso H., Haidara M., Ferry G., Nepveu F., Boutin J. A., Reybier K. (2019). Antimalarial properties of dunnione derivatives as NQO2 substrates. Molecules, 24, p. art. 3697 [11 p.].

Titre du document
Antimalarial properties of dunnione derivatives as NQO2 substrates
Année de publication
2019
Type de document
Article référencé dans le Web of Science WOS:000496249500066
Auteurs
Chhour M., Aubouy Agnès, Bourgeade-Delmas Sandra, Perio Pierre, Ternet-Fontebasso H., Haidara M., Ferry G., Nepveu F., Boutin J. A., Reybier K.
Source
Molecules, 2019, 24, p. art. 3697 [11 p.]
Dunnione, a natural product isolated from the leaves of Streptocarpus dunnii (Gesneriaceae), acts as a substrate for quinone-reductases that may be associated with its antimalarial properties. Following our exploration of reactive oxygen species-producing compounds such as indolones, as possible new approaches for the research of new ways to treat this parasitosis, we explored derivatives of this natural product and their possible antiplasmodial and antimalarial properties, in vitro and in vivo, respectively. Apart from one compound, all the products tested had weak to moderate antiplasmodial activities, the best IC50 value being equal to 0.58 mu M. In vivo activities in the murine model were moderate (at a dose of 50 mg/kg/mice, five times higher than the dose of chloroquine). These results encourage further pharmacomodulation steps to improve the targeting of the parasitized red blood cells and antimalarial activities.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052] ; Sciences du monde végétal [076]
Localisation
Fonds IRD [F B010077320]
Identifiant IRD
fdi:010077320
Contact