@article{fdi:010077320,
  title = {{A}ntimalarial properties of dunnione derivatives as {NQO}2 substrates},
  author = {{C}hhour, {M}. and {A}ubouy, {A}gn{\`e}s and {B}ourgeade-{D}elmas, {S}andra and {P}erio, {P}ierre and {T}ernet-{F}ontebasso, {H}. and {H}aidara, {M}. and {F}erry, {G}. and {N}epveu, {F}. and {B}outin, {J}. {A}. and {R}eybier, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{D}unnione, a natural product isolated from the leaves of {S}treptocarpus dunnii ({G}esneriaceae), acts as a substrate for quinone-reductases that may be associated with its antimalarial properties. {F}ollowing our exploration of reactive oxygen species-producing compounds such as indolones, as possible new approaches for the research of new ways to treat this parasitosis, we explored derivatives of this natural product and their possible antiplasmodial and antimalarial properties, in vitro and in vivo, respectively. {A}part from one compound, all the products tested had weak to moderate antiplasmodial activities, the best {IC}50 value being equal to 0.58 mu {M}. {I}n vivo activities in the murine model were moderate (at a dose of 50 mg/kg/mice, five times higher than the dose of chloroquine). {T}hese results encourage further pharmacomodulation steps to improve the targeting of the parasitized red blood cells and antimalarial activities.},
  keywords = {dunnione analogues ; {P}lasmodium spp ; drug discovery ; in vivo efficacy ; malaria},
  booktitle = {},
  journal = {{M}olecules},
  volume = {24},
  numero = {},
  pages = {art. 3697 [11 p.]},
  year = {2019},
  DOI = {10.3390/molecules24203697},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077320},
}