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Kawilapat S., Salvadori Nicolas, Ngo-Giang-Huong Nicole, Decker Luc, Kanjanavanit S., Puangsombat A., Preedisripipat K., Lertpienthum N., Akarathum N., Mekmullica J., Srirompotong U., Lallemant Marc, Le Coeur S., Traisaithit P., Leroi C., Gonzague Jourdain. (2019). Incidence and risk factors of loss to follow-up among HIV-infected children in an antiretroviral treatment program . PloS One, 14 (9), art. no 0222082 [10 p. en ligne] ISSN 1932-6203

Lien direct chez l'éditeur doi:10.1371/journal.pone.0222082

En Libre Accès sur HAL https://hal.archives-ouvertes.fr/hal-02326350

Titre
Incidence and risk factors of loss to follow-up among HIV-infected children in an antiretroviral treatment program
Année de publication2019
Type de documentArticle
AuteursKawilapat S., Salvadori Nicolas, Ngo-Giang-Huong Nicole, Decker Luc, Kanjanavanit S., Puangsombat A., Preedisripipat K., Lertpienthum N., Akarathum N., Mekmullica J., Srirompotong U., Lallemant Marc, Le Coeur S., Traisaithit P., Leroi C., Gonzague Jourdain.
SourcePloS One, 2019, 14 (9), art. no 0222082 [10 p. en ligne] ISSN 1932-6203
RésuméIntroduction : The success of antiretroviral treatment (ART) programs can be compromised by high rates of patient loss to follow-up (LTFU). We assessed the incidence and risk factors of LTFU in a large cohort of HIV-infected children receiving ART in Thailand. Methods : All children participating in a multicenter cohort (NCT00433030) between 1999 and 2014 were included. The date of LTFU was 9 months after the last contact date. ART interruption was defined as ART discontinuation for more than 7 days followed by resumption of treatment. Baseline and time-dependent risk factors associated with LTFU were identified using Fine and Gray competing risk regression models with death or referral to another hospital as competing events. Results : Of 873 children who were followed during a median of 8.6 years (interquartile range 4.5–10.6), 196 were LTFU, 73 died, and 195 referred. The cumulative incidence of LTFU was2.9% at 1 year, 7.3% at 5 years and 22.2% at 10 years. Children aged 13 years and more had a 3-fold higher risk (95% confidence interval 2.06–4.78) of LTFU than those younger. Children who had interrupted ART within the previous year had a 2.5-fold higher risk (1.12–5.91) than those who had not. The risk of LTFU was lower in children stunted (height-forage Z-scores <-2 SD) (0.42–0.96) or underweight (weight-for-age Z-scores <-2 SD) (0.24–0.97). Conclusion : Adolescence, ART interruption and absence of growth deficit were associated with LTFU. These may be warnings that should draw clinicians’ attention and possibly trigger specificinterventions. Children with no significant growth retardation may also be at risk of LTFU.
Plan de classementMaladies sexuellement transmissibles [052MALTRA03] ; Epidémiologie générale [050EPID]
LocalisationFonds IRD [F B010076956]
Identifiant IRDfdi:010076956
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010076956

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