@article{fdi:010076956,
  title = {{I}ncidence and risk factors of loss to follow-up among {HIV}-infected children in an antiretroviral treatment program},
  author = {{K}awilapat, {S}. and {S}alvadori, {N}icolas and {N}go-{G}iang-{H}uong, {N}icole and {D}ecker, {L}uc and {K}anjanavanit, {S}. and {P}uangsombat, {A}. and {P}reedisripipat, {K}. and {L}ertpienthum, {N}. and {A}karathum, {N}. and {M}ekmullica, {J}. and {S}rirompotong, {U}. and {L}allemant, {M}arc and {L}e {C}oeur, {S}. and {T}raisaithit, {P}. and {L}eroi, {C}. and {J}ourdain, {G}onzague},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction : {T}he success of antiretroviral treatment ({ART}) programs can be compromised by high rates of patient loss to follow-up ({LTFU}). {W}e assessed the incidence and risk factors of {LTFU} in a large cohort of {HIV}-infected children receiving {ART} in {T}hailand. {M}ethods : {A}ll children participating in a multicenter cohort ({NCT}00433030) between 1999 and 2014 were included. {T}he date of {LTFU} was 9 months after the last contact date. {ART} interruption was defined as {ART} discontinuation for more than 7 days followed by resumption of treatment. {B}aseline and time-dependent risk factors associated with {LTFU} were identified using {F}ine and {G}ray competing risk regression models with death or referral to another hospital as competing events. {R}esults : {O}f 873 children who were followed during a median of 8.6 years (interquartile range 4.5-10.6), 196 were {LTFU}, 73 died, and 195 referred. {T}he cumulative incidence of {LTFU} was 2.9% at 1 year, 7.3% at 5 years and 22.2% at 10 years. {C}hildren aged 13 years and more had a 3-fold higher risk (95% confidence interval 2.06-4.78) of {LTFU} than those younger. {C}hildren who had interrupted {ART} within the previous year had a 2.5-fold higher risk (1.12-5.91) than those who had not. {T}he risk of {LTFU} was lower in children stunted (height-forage {Z}-scores <-2 {SD}) (0.42-0.96) or underweight (weight-for-age {Z}-scores <-2 {SD}) (0.24-0.97). {C}onclusion : {A}dolescence, {ART} interruption and absence of growth deficit were associated with {LTFU}. {T}hese may be warnings that should draw clinicians' attention and possibly trigger specificinterventions. {C}hildren with no significant growth retardation may also be at risk of {LTFU}.},
  keywords = {{THAILANDE}},
  booktitle = {},
  journal = {{P}lo{S} {O}ne},
  volume = {14},
  numero = {9},
  pages = {art. no 0222082 [10  en ligne]},
  ISSN = {1932-6203},
  year = {2019},
  DOI = {10.1371/journal.pone.0222082},
  URL = {https://www.documentation.ird.fr/hor/fdi:010076956},
}