Vu Tien Viet Dung, Do Thi Thuy Nga, Rydell U., Nilsson L.E., Olson L., Larsson M., Hanberger H., Choisy Marc, Dao Tuyet Trinh, van Doorn H.R., Nguyen Van Kinh, Nguyen Vu Trung, Wertheim H.F.L., VINARES Consortium. (2019). Antimicrobial susceptibility testing and antibiotic consumption results from 16 hospitals in Viet Nam : the VINARES project 2012-2013. Journal of Global Antimicrobial Resistance, 18, p. 269-278. ISSN 2213-7165.
Titre du document
Antimicrobial susceptibility testing and antibiotic consumption results from 16 hospitals in Viet Nam : the VINARES project 2012-2013
Année de publication
2019
Auteurs
Vu Tien Viet Dung, Do Thi Thuy Nga, Rydell U., Nilsson L.E., Olson L., Larsson M., Hanberger H., Choisy Marc, Dao Tuyet Trinh, van Doorn H.R., Nguyen Van Kinh, Nguyen Vu Trung, Wertheim H.F.L., VINARES Consortium
Source
Journal of Global Antimicrobial Resistance, 2019,
18, p. 269-278 ISSN 2213-7165
Objective : To establish a hospital-based surveillance network with national coverage for antimicrobial resistance (AMR) and antibiotic consumption in Viet Nam. Methods : A 16-hospital network (Viet Nam Resistance: VINARES) was established and consisted of national and provincial-level hospitals across the country. Antimicrobial susceptibility testing results from routine clinical diagnostic specimens and antibiotic consumption data in Defined Daily Dose per 1000 bed days (DDD/1000 patient-days) were prospectively collected and analysed between October 2012 and September 2013. Results : Data from a total of 24 732 de-duplicated clinical isolates were reported. The most common bacteria were: Escherichia coli (4437 isolates, 18%), Klebsiella spp. (3290 isolates, 13%) and Acinetobacter spp. (2895 isolates, 12%). The hospital average antibiotic consumption was 918 DDD/1000 patient-days. Third-generation cephalosporins were the most frequently used antibiotic class (223 DDD/1000 patient-days, 24%), followed by fluoroquinolones (151 DDD/1000 patient-days, 16%) and second-generation cephalosporins (112 DDD/1000 patient-days, 12%). Proportions of antibiotic resistance were high: 1098/1580 (69%) Staphylococcus aureus isolates were methicillin-resistant (MRSA); 115/344 isolates (33%) and 90/358 (25%) Streptococcus pneumoniae had reduced susceptibility to penicillin and ceftriaxone, respectively. A total of 180/2977 (6%) E. coli and 242/1526 (16%) Klebsiella pneumoniae were resistant to imipenem, respectively; 602/1826 (33%) Pseudomonas aeruginosa were resistant to ceftazidime and 578/1765 (33%) to imipenem. Of Acinetobacter spp. 1495/2138 (70%) were resistant to carbapenems and 2/333 (1%) to colistin. Conclusions : These data are valuable in providing a baseline for AMR among common bacterial pathogens in Vietnamese hospitals and to assess the impact of interventions.
Plan de classement
Santé : généralités [050]
Localisation
Fonds IRD [F B010076739]
Identifiant IRD
fdi:010076739
