%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Vu Tien Viet Dung
%A Do Thi Thuy Nga
%A Rydell, U.
%A Nilsson, L.E.
%A Olson, L.
%A Larsson, M.
%A Hanberger, H.
%A Choisy, Marc
%A Dao Tuyet Trinh
%A van Doorn, H.R.
%A Nguyen Van Kinh
%A Nguyen Vu Trung
%A Wertheim, H.F.L.
%A VINARES Consortium
%T Antimicrobial susceptibility testing and antibiotic consumption results from 16 hospitals in Viet Nam : the VINARES project 2012-2013
%D 2019
%L fdi:010076739
%G ENG
%J Journal of Global Antimicrobial Resistance
%@ 2213-7165
%K VIET NAM
%M ISI:0004856611700055
%P 269-278
%R 10.1016/j.jgar.2019.06.002
%U https://www.documentation.ird.fr/hor/fdi:010076739
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers19-08/010076739.pdf
%V 18
%W Horizon (IRD)
%X Objective : To establish a hospital-based surveillance network with national coverage for antimicrobial resistance (AMR) and antibiotic consumption in Viet Nam. Methods : A 16-hospital network (Viet Nam Resistance: VINARES) was established and consisted of national and provincial-level hospitals across the country. Antimicrobial susceptibility testing results from routine clinical diagnostic specimens and antibiotic consumption data in Defined Daily Dose per 1000 bed days (DDD/1000 patient-days) were prospectively collected and analysed between October 2012 and September 2013. Results : Data from a total of 24 732 de-duplicated clinical isolates were reported. The most common bacteria were: Escherichia coli (4437 isolates, 18%), Klebsiella spp. (3290 isolates, 13%) and Acinetobacter spp. (2895 isolates, 12%). The hospital average antibiotic consumption was 918 DDD/1000 patient-days. Third-generation cephalosporins were the most frequently used antibiotic class (223 DDD/1000 patient-days, 24%), followed by fluoroquinolones (151 DDD/1000 patient-days, 16%) and second-generation cephalosporins (112 DDD/1000 patient-days, 12%). Proportions of antibiotic resistance were high: 1098/1580 (69%) Staphylococcus aureus isolates were methicillin-resistant (MRSA); 115/344 isolates (33%) and 90/358 (25%) Streptococcus pneumoniae had reduced susceptibility to penicillin and ceftriaxone, respectively. A total of 180/2977 (6%) E. coli and 242/1526 (16%) Klebsiella pneumoniae were resistant to imipenem, respectively; 602/1826 (33%) Pseudomonas aeruginosa were resistant to ceftazidime and 578/1765 (33%) to imipenem. Of Acinetobacter spp. 1495/2138 (70%) were resistant to carbapenems and 2/333 (1%) to colistin. Conclusions : These data are valuable in providing a baseline for AMR among common bacterial pathogens in Vietnamese hospitals and to assess the impact of interventions.
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