Perez-Quintero A. L., Szurek Boris. (2019). A decade decoded : spies and hackers in the history of TAL effectors research. Annual Review of Phytopathology, 57, p. 459-481. ISBN 978-0-8243-1357-9.
Titre du document
A decade decoded : spies and hackers in the history of TAL effectors research
Annual Review of Phytopathology, 2019,
57, p. 459-481 ISBN 978-0-8243-1357-9
Transcription activator-like effectors (TALEs) from the genus Xanthomonas are proteins with the remarkable ability to directly bind the promoters of genes in the plant host to induce their expression, which often helps bacterial colonization. Metaphorically, TALEs act as spies that infiltrate the plant disguised as high-ranking civilians (transcription factors) to trick the plant into activating weak points that allow an invasion. Current knowledge of how TALEs operate allows researchers to predict their activity (counterespionage) and exploit their function, engineering them to do our bidding (a Manchurian agent). This has been possible thanks particularly to the discovery of their DNA binding mechanism, which obeys specific amino acid-DNA correspondences (the TALE code). Here, we review the history of how researchers discovered the way these proteins work and what has changed in the ten years since the discovery of the code. Recommended music for reading this review can be found in the Supplemental Material.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Sciences du monde végétal [076]
