Publications des scientifiques de l'IRD

Liu W. M., Li Y. Y., Shaw K. S., Learn G. H., Plenderleith L. J., Malenke J. A., Sundararaman S. A., Ramirez M. A., Crystal P. A., Smith A. G., Bibollet-Ruche F., Ayouba Ahidjo, Locatelli Sabrina, Esteban Amandine, Mouacha Fatima, Guichet Emilande, Butel Christelle, Ahuka-Mundeke S., Inogwabini B. I., Ndjango J. B. N., Speede S., Sanz C. M., Morgan D. B., Gonder M. K., Kranzusch P. J., Walsh P. D., Georgiev A. V., Muller M. N., Piel A. K., Stewart F. A., Wilson M. L., Pusey A. E., Cui L. W., Wang Z. L., Farnert A., Sutherland C. J., Nolder D., Hart J. A., Hart T. B., Bertolani P., Gillis A., LeBreton M., Tafon B., Kiyang J., Djoko C. F., Schneider B. S., Wolfe N. D., Mpoudi-Ngole E., Delaporte Eric, Carter R., Culleton R. L., Shaw G. M., Rayner J. C., Peeters Martine, Hahn B. H., Sharp P. M. (2014). African origin of the malaria parasite Plasmodium vivax. Nature Communications, 5, 3346. ISSN 2041-1723.

Titre du document
African origin of the malaria parasite Plasmodium vivax
Année de publication
2014
Type de document
Article référencé dans le Web of Science WOS:000332669600001
Auteurs
Liu W. M., Li Y. Y., Shaw K. S., Learn G. H., Plenderleith L. J., Malenke J. A., Sundararaman S. A., Ramirez M. A., Crystal P. A., Smith A. G., Bibollet-Ruche F., Ayouba Ahidjo, Locatelli Sabrina, Esteban Amandine, Mouacha Fatima, Guichet Emilande, Butel Christelle, Ahuka-Mundeke S., Inogwabini B. I., Ndjango J. B. N., Speede S., Sanz C. M., Morgan D. B., Gonder M. K., Kranzusch P. J., Walsh P. D., Georgiev A. V., Muller M. N., Piel A. K., Stewart F. A., Wilson M. L., Pusey A. E., Cui L. W., Wang Z. L., Farnert A., Sutherland C. J., Nolder D., Hart J. A., Hart T. B., Bertolani P., Gillis A., LeBreton M., Tafon B., Kiyang J., Djoko C. F., Schneider B. S., Wolfe N. D., Mpoudi-Ngole E., Delaporte Eric, Carter R., Culleton R. L., Shaw G. M., Rayner J. C., Peeters Martine, Hahn B. H., Sharp P. M.
Source
Nature Communications, 2014, 5, 3346 ISSN 2041-1723
Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is absent from most of central Africa due to the near fixation of a mutation that inhibits the expression of its receptor, the Duffy antigen, on human erythrocytes. The emergence of this protective allele is not understood because P. vivax is believed to have originated in Asia. Here we show, using a non-invasive approach, that wild chimpanzees and gorillas throughout central Africa are endemically infected with parasites that are closely related to human P. vivax. Sequence analyses reveal that ape parasites lack host specificity and are much more diverse than human parasites, which form a monophyletic lineage within the ape parasite radiation. These findings indicate that human P. vivax is of African origin and likely selected for the Duffy-negative mutation. All extant human P. vivax parasites are derived from a single ancestor that escaped out of Africa.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010075336]
Identifiant IRD
fdi:010075336
Contact