@article{fdi:010075336,
  title = {{A}frican origin of the malaria parasite {P}lasmodium vivax},
  author = {{L}iu, {W}. {M}. and {L}i, {Y}. {Y}. and {S}haw, {K}. {S}. and {L}earn, {G}. {H}. and {P}lenderleith, {L}. {J}. and {M}alenke, {J}. {A}. and {S}undararaman, {S}. {A}. and {R}amirez, {M}. {A}. and {C}rystal, {P}. {A}. and {S}mith, {A}. {G}. and {B}ibollet-{R}uche, {F}. and {A}youba, {A}hidjo and {L}ocatelli, {S}abrina and {E}steban, {A}mandine and {M}ouacha, {F}atima and {G}uichet, {E}milande and {B}utel, {C}hristelle and {A}huka-{M}undeke, {S}. and {I}nogwabini, {B}. {I}. and {N}django, {J}. {B}. {N}. and {S}peede, {S}. and {S}anz, {C}. {M}. and {M}organ, {D}. {B}. and {G}onder, {M}. {K}. and {K}ranzusch, {P}. {J}. and {W}alsh, {P}. {D}. and {G}eorgiev, {A}. {V}. and {M}uller, {M}. {N}. and {P}iel, {A}. {K}. and {S}tewart, {F}. {A}. and {W}ilson, {M}. {L}. and {P}usey, {A}. {E}. and {C}ui, {L}. {W}. and {W}ang, {Z}. {L}. and {F}arnert, {A}. and {S}utherland, {C}. {J}. and {N}older, {D}. and {H}art, {J}. {A}. and {H}art, {T}. {B}. and {B}ertolani, {P}. and {G}illis, {A}. and {L}e{B}reton, {M}. and {T}afon, {B}. and {K}iyang, {J}. and {D}joko, {C}. {F}. and {S}chneider, {B}. {S}. and {W}olfe, {N}. {D}. and {M}poudi-{N}gole, {E}. and {D}elaporte, {E}ric and {C}arter, {R}. and {C}ulleton, {R}. {L}. and {S}haw, {G}. {M}. and {R}ayner, {J}. {C}. and {P}eeters, {M}artine and {H}ahn, {B}. {H}. and {S}harp, {P}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}lasmodium vivax is the leading cause of human malaria in {A}sia and {L}atin {A}merica but is absent from most of central {A}frica due to the near fixation of a mutation that inhibits the expression of its receptor, the {D}uffy antigen, on human erythrocytes. {T}he emergence of this protective allele is not understood because {P}. vivax is believed to have originated in {A}sia. {H}ere we show, using a non-invasive approach, that wild chimpanzees and gorillas throughout central {A}frica are endemically infected with parasites that are closely related to human {P}. vivax. {S}equence analyses reveal that ape parasites lack host specificity and are much more diverse than human parasites, which form a monophyletic lineage within the ape parasite radiation. {T}hese findings indicate that human {P}. vivax is of {A}frican origin and likely selected for the {D}uffy-negative mutation. {A}ll extant human {P}. vivax parasites are derived from a single ancestor that escaped out of {A}frica.},
  keywords = {{MALARIA} ; {AFRIQUE} ; {CAMEROUN}},
  booktitle = {},
  journal = {{N}ature {C}ommunications},
  volume = {5},
  numero = {},
  pages = {3346},
  ISSN = {2041-1723},
  year = {2014},
  URL = {https://www.documentation.ird.fr/hor/fdi:010075336},
}