Sagaon Teyssier Luis, Mabire X., Laguette V., Fressard L., Suzan-Monti M., Rojas Castro D., Hall N., Capitant C., Meyer L., Chidiac C., Tremblay C., Preau M., Spire B., Molina J. M., ANRS IPERGAY Study Group. (2018). A group-based trajectory model for changes in pre-exposure prophylaxis and condom use among men who have sex with men participating in the ANRS IPERGAY trial. Aids Patient Care and Stds, 32 (12), p. 495-510. ISSN 1087-2914.
Titre du document
A group-based trajectory model for changes in pre-exposure prophylaxis and condom use among men who have sex with men participating in the ANRS IPERGAY trial
Année de publication
2018
Auteurs
Sagaon Teyssier Luis, Mabire X., Laguette V., Fressard L., Suzan-Monti M., Rojas Castro D., Hall N., Capitant C., Meyer L., Chidiac C., Tremblay C., Preau M., Spire B., Molina J. M., ANRS IPERGAY Study Group
Source
Aids Patient Care and Stds, 2018,
32 (12), p. 495-510 ISSN 1087-2914
Pre-exposure prophylaxis (PrEP) is one of the most important milestones in HIV prevention for high-risk HIV-negative people. The introduction of PrEP into the HIV prevention package has raised the question of possible risk compensation, and in particular, a reduction in condom use. Although open-label extension (OLE) studies have enabled investigators to examine risk compensation in more real-life settings, results to date have been inconclusive regarding PrEP-induced behavioral changes. We aimed to identify behavioral trajectories over time for PrEP and condom use, and to investigate the link between these trajectories. Group-based trajectory modeling using logistic specification was implemented. Data of the 332 individuals participating in the double-blind and OLE phases of ANRS IPERGAY were used. Four distinct group trajectories were identified: 49.7% of the participants had "systematic adherence to PrEP," 19% had "high adherence to PrEP, 15.3% had "declining adherence to PrEP," and 16% had "low adherence to PrEP." Two condom trajectories were identified: 53% (n = 176) of the 332 participants were "low-level users" of condoms, and 47% were "high-level users." Among the former, 24.4% also belonged to the "low adherence to PrEP" group. This most-at-risk group represented 13% of all the participants. The effectiveness of offering sexual activity-based PrEP as part of the French HIV prevention package in the ANRS IPERGAY clinical trial is demonstrated by the relatively small proportion of participants that offset their low-level condom use with PrEP adherence. The results from this work may help in the future development of tailored prevention programs for high-risk HIV-negative people.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
;
Santé : aspects socioculturels, économiques et politiques [056]
Description Géographique
FRANCE ; CANADA
Localisation
Fonds IRD [F B010074931]
Identifiant IRD
fdi:010074931
