Population structure of a vector of human diseases : Aedes aegypti in its ancestral range, Africa

2018

Article référencé dans le Web of Science WOS:000444946300009

Kotsakiozi P., Evans B. R., Gloria-Soria A., Kamgang B., Mayanja M., Lutwama J., Le Goff Gilbert, Ayala Diego, Paupy Christophe, Badolo A., Pinto J., Sousa C. A., Troco A. D., Powell J. R.

Ecology and Evolution, 2018, 8 (16), p. 7835-7848 ISSN 2045-7758

Aedes aegypti, the major vector of dengue, yellow fever, chikungunya, and Zika viruses, remains of great medical and public health concern. There is little doubt that the ancestral home of the species is Africa. This mosquito invaded the New World 400-500years ago and later, Asia. However, little is known about the genetic structure and history of Ae.aegypti across Africa, as well as the possible origin(s) of the New World invasion. Here, we use similar to 17,000 genome-wide single nucleotide polymorphisms (SNPs) to characterize a heretofore undocumented complex picture of this mosquito across its ancestral range in Africa. We find signatures of human-assisted migrations, connectivity across long distances in sylvan populations, and of local admixture between domestic and sylvan populations. Finally, through a phylogenetic analysis combined with the genetic structure analyses, we suggest West Africa and especially Angola as the source of the New World's invasion, a scenario that fits well with the historic record of 16th-century slave trade between Africa and Americas.

Entomologie médicale / Parasitologie / Virologie [052]

AFRIQUE SUBSAHARIENNE ; ASIE ; AMERIQUE LATINE

Fonds IRD [F B010074053]

fdi:010074053