Publications des scientifiques de l'IRD

Cooper A., Ilboudo H., Alibu V. P., Ravel Sophie, Enyaru J., Weir W., Noyes H., Capewell P., Camara M., Milet Jacqueline, Jamonneau Vincent, Camara O., Matovu E., Bucheton Bruno, MacLeod A. (2017). APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis. eLife, 6, p. e25461 [18 p.]. ISSN 2050-084X.

Titre du document
APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis
Année de publication
2017
Type de document
Article référencé dans le Web of Science WOS:000404593700001
Auteurs
Cooper A., Ilboudo H., Alibu V. P., Ravel Sophie, Enyaru J., Weir W., Noyes H., Capewell P., Camara M., Milet Jacqueline, Jamonneau Vincent, Camara O., Matovu E., Bucheton Bruno, MacLeod A.
Source
eLife, 2017, 6, p. e25461 [18 p.] ISSN 2050-084X
Reduced susceptibility to infectious disease can increase the frequency of otherwise deleterious alleles. In populations of African ancestry, two apolipoprotein-L1 (APOL1) variants with a recessive kidney disease risk, named G1 and G2, occur at high frequency. APOL1 is a trypanolytic protein that confers innate resistance to most African trypanosomes, but not Trypanosoma brucei rhodesiense or T.b. gambiense, which cause human African trypanosomiasis. In this case-control study, we test the prevailing hypothesis that these APOL1 variants reduce trypanosomiasis susceptibility, resulting in their positive selection in sub-Saharan Africa. We demonstrate a five-fold dominant protective association for G2 against T.b. rhodesiense infection. Furthermore, we report unpredicted strong opposing associations with T.b. gambiense disease outcome. G2 associates with faster progression of T.b. gambiense trypanosomiasis, while G1 associates with asymptomatic carriage and undetectable parasitemia. These results implicate both forms of human African trypanosomiasis in the selection and persistence of otherwise detrimental APOL1 kidney disease variants.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
AFRIQUE SUBSAHARIENNE
Localisation
Fonds IRD [F B010070329]
Identifiant IRD
fdi:010070329
Contact