Multidisciplinary assessment of post-Ebola sequelae in Guinea (Postebogui) : an observational cohort study

2017

Article référencé dans le Web of Science WOS:000399521800044

Etard Jean-François, Sow M. S., Leroy S., Touré A., Taverne Bernard, Keita Alpha Kabinet, Msellati Philippe, Magassouba N., Baize S., Raoul H., Izard Suzanne, Kpamou C., March Laura, Savane I., Barry M., Delaporte E., Postebogui Study Group

Lancet Infectious Diseases, 2017, 17 (5), p. 545-552 ISSN 1473-3099

Background The high number of survivors from the 2013-16 west African outbreak of Ebola virus disease (EVD) has raised several new issues: long-term clinical complications, psychosocial consequences, risks of EVD reactivation, and secondary transmission due to viral persistence in body fluids. We aimed to assess long-term clinical, psychosocial, and viral outcomes in EVD survivors in Guinea. Methods In this multidisciplinary observational cohort study, we recruited patients aged 1 year or more in four sites in Guinea (Donka National Hospital, Conakry; Macenta Prefectoral Hospital, Macenta; N'zerekore Regional Hospital, N'zerekore; and Forecariah Prefectoral Hospital, Forecariah) following discharge from any Ebola treatment centre in Guinea. Eligible patients had had laboratory-confirmed EVD and had then been declared clear of the virus in the blood. All consenting patients were included, with no exclusion criteria. Trained dinicians assessed patients at enrolment to the cohort, recording clinical symptoms and signs of depression. We did routine blood examinations and examined viral persistence in body fluids using RT-PCR. We did psychological evaluations using questionnaires developed for different age groups. Follow-up is planned to 2 years, and here we present findings at enrolment. Findings Between March 23, 2015, and July 11, 2016, we recruited 802 patients, of whom 360 (45%) were male, 442 (55%) were female; 158 (20%) were younger than 18 years. The median age was 28.4 years (range 1.0-79.9, IQR 19.4-39.8). The median delay after discharge was 350 days (IQR 223-491). The most frequent symptoms were general symptoms (324 [40%] patients), musculoskeletal pain (303 [38%]), headache (278 [35%]), depression (124 [17%] of 713 responses), abdominal pain (178 [22%]), and ocular disorders (142 [18%]). More adults than children had at least one clinical symptom (505 [78%] vs 101 [64%], p<0.0003), ocular complications (124 [19%] vs 18 [11%], p=0.0200), or musculoskeletal symptoms (274 [43%] vs 29 [18%], p<0.0001). A positive RT-PCR in semen was found in ten (5%) of 188 men, at a maximum of 548 days after disease onset. 204 (26%) of 793 patients reported stigmatisation. Ocular complications were more frequent at enrolment than at discharge (142 [18%] vs 61 [8%] patients). Interpretation Post-EVD symptoms can remain long after recovery and long-term viral persistence in semen is confirmed. The results justify calls for regular check-ups of survivors at least 18 months after recovery.

Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052] ; Santé : aspects socioculturels, économiques et politiques [056]

GUINEE

Fonds IRD [F B010069506]

fdi:010069506