@article{fdi:010069506,
  title = {{M}ultidisciplinary assessment of post-{E}bola sequelae in {G}uinea ({P}ostebogui) : an observational cohort study},
  author = {{E}tard, {J}ean-{F}ran{\c{c}}ois and {S}ow, {M}. {S}. and {L}eroy, {S}. and {T}our{\'e}, {A}. and {T}averne, {B}ernard and {K}eita, {A}lpha {K}abinet and {M}sellati, {P}hilippe and {M}agassouba, {N}. and {B}aize, {S}. and {R}aoul, {H}. and {I}zard, {S}uzanne and {K}pamou, {C}. and {M}arch, {L}aura and {S}avane, {I}. and {B}arry, {M}. and {D}elaporte, {E}. and {P}ostebogui {S}tudy {G}roup,},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {T}he high number of survivors from the 2013-16 west {A}frican outbreak of {E}bola virus disease ({EVD}) has raised several new issues: long-term clinical complications, psychosocial consequences, risks of {EVD} reactivation, and secondary transmission due to viral persistence in body fluids. {W}e aimed to assess long-term clinical, psychosocial, and viral outcomes in {EVD} survivors in {G}uinea. {M}ethods {I}n this multidisciplinary observational cohort study, we recruited patients aged 1 year or more in four sites in {G}uinea ({D}onka {N}ational {H}ospital, {C}onakry; {M}acenta {P}refectoral {H}ospital, {M}acenta; {N}'zerekore {R}egional {H}ospital, {N}'zerekore; and {F}orecariah {P}refectoral {H}ospital, {F}orecariah) following discharge from any {E}bola treatment centre in {G}uinea. {E}ligible patients had had laboratory-confirmed {EVD} and had then been declared clear of the virus in the blood. {A}ll consenting patients were included, with no exclusion criteria. {T}rained dinicians assessed patients at enrolment to the cohort, recording clinical symptoms and signs of depression. {W}e did routine blood examinations and examined viral persistence in body fluids using {RT}-{PCR}. {W}e did psychological evaluations using questionnaires developed for different age groups. {F}ollow-up is planned to 2 years, and here we present findings at enrolment. {F}indings {B}etween {M}arch 23, 2015, and {J}uly 11, 2016, we recruited 802 patients, of whom 360 (45%) were male, 442 (55%) were female; 158 (20%) were younger than 18 years. {T}he median age was 28.4 years (range 1.0-79.9, {IQR} 19.4-39.8). {T}he median delay after discharge was 350 days ({IQR} 223-491). {T}he most frequent symptoms were general symptoms (324 [40%] patients), musculoskeletal pain (303 [38%]), headache (278 [35%]), depression (124 [17%] of 713 responses), abdominal pain (178 [22%]), and ocular disorders (142 [18%]). {M}ore adults than children had at least one clinical symptom (505 [78%] vs 101 [64%], p<0.0003), ocular complications (124 [19%] vs 18 [11%], p=0.0200), or musculoskeletal symptoms (274 [43%] vs 29 [18%], p<0.0001). {A} positive {RT}-{PCR} in semen was found in ten (5%) of 188 men, at a maximum of 548 days after disease onset. 204 (26%) of 793 patients reported stigmatisation. {O}cular complications were more frequent at enrolment than at discharge (142 [18%] vs 61 [8%] patients). {I}nterpretation {P}ost-{EVD} symptoms can remain long after recovery and long-term viral persistence in semen is confirmed. {T}he results justify calls for regular check-ups of survivors at least 18 months after recovery.},
  keywords = {{GUINEE}},
  booktitle = {},
  journal = {{L}ancet {I}nfectious {D}iseases},
  volume = {17},
  numero = {5},
  pages = {545--552},
  ISSN = {1473-3099},
  year = {2017},
  DOI = {10.1016/s1473-3099(16)30516-3},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069506},
}