Publications des scientifiques de l'IRD

Capewell P., Cren-Travaille C., Marchesi F., Johnston P., Clucas C., Benson R. A., Gorman T. A., Calvo-Alvarez E., Crouzols A., Jouvion G., Jamonneau Vincent, Weir W., Stevenson M. L., O'Neill K., Cooper A., Swar N. R. K., Bucheton Bruno, Ngoyi D. M., Garside P., Rotureau B., MacLeod A. (2016). The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes. eLife, 5, p. e17716 [17 p.]. ISSN 2050-084X.

Titre du document
The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes
Année de publication
2016
Type de document
Article référencé dans le Web of Science WOS:000386454200001
Auteurs
Capewell P., Cren-Travaille C., Marchesi F., Johnston P., Clucas C., Benson R. A., Gorman T. A., Calvo-Alvarez E., Crouzols A., Jouvion G., Jamonneau Vincent, Weir W., Stevenson M. L., O'Neill K., Cooper A., Swar N. R. K., Bucheton Bruno, Ngoyi D. M., Garside P., Rotureau B., MacLeod A.
Source
eLife, 2016, 5, p. e17716 [17 p.] ISSN 2050-084X
The role of mammalian skin in harbouring and transmitting arthropod-borne protozoan parasites has been overlooked for decades as these pathogens have been regarded primarily as blood-dwelling organisms. Intriguingly, infections with low or undetected blood parasites are common, particularly in the case of Human African Trypanosomiasis caused by Trypanosoma brucei gambiense. We hypothesise, therefore, the skin represents an anatomic reservoir of infection. Here we definitively show that substantial quantities of trypanosomes exist within the skin following experimental infection, which can be transmitted to the tsetse vector, even in the absence of detectable parasitaemia. Importantly, we demonstrate the presence of extravascular parasites in human skin biopsies from undiagnosed individuals. The identification of this novel reservoir requires a re-evaluation of current diagnostic methods and control policies. More broadly, our results indicate that transmission is a key evolutionary force driving parasite extravasation that could further result in tissue invasion-dependent pathology.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052] ; Sciences du monde animal [080]
Description Géographique
AFRIQUE
Localisation
Fonds IRD [F B010068311]
Identifiant IRD
fdi:010068311
Contact