@article{fdi:010068311,
  title = {{T}he skin is a significant but overlooked anatomical reservoir for vector-borne {A}frican trypanosomes},
  author = {{C}apewell, {P}. and {C}ren-{T}ravaille, {C}. and {M}archesi, {F}. and {J}ohnston, {P}. and {C}lucas, {C}. and {B}enson, {R}. {A}. and {G}orman, {T}. {A}. and {C}alvo-{A}lvarez, {E}. and {C}rouzols, {A}. and {J}ouvion, {G}. and {J}amonneau, {V}incent and {W}eir, {W}. and {S}tevenson, {M}. {L}. and {O}'{N}eill, {K}. and {C}ooper, {A}. and {S}war, {N}. {R}. {K}. and {B}ucheton, {B}runo and {N}goyi, {D}. {M}. and {G}arside, {P}. and {R}otureau, {B}. and {M}ac{L}eod, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he role of mammalian skin in harbouring and transmitting arthropod-borne protozoan parasites has been overlooked for decades as these pathogens have been regarded primarily as blood-dwelling organisms. {I}ntriguingly, infections with low or undetected blood parasites are common, particularly in the case of {H}uman {A}frican {T}rypanosomiasis caused by {T}rypanosoma brucei gambiense. {W}e hypothesise, therefore, the skin represents an anatomic reservoir of infection. {H}ere we definitively show that substantial quantities of trypanosomes exist within the skin following experimental infection, which can be transmitted to the tsetse vector, even in the absence of detectable parasitaemia. {I}mportantly, we demonstrate the presence of extravascular parasites in human skin biopsies from undiagnosed individuals. {T}he identification of this novel reservoir requires a re-evaluation of current diagnostic methods and control policies. {M}ore broadly, our results indicate that transmission is a key evolutionary force driving parasite extravasation that could further result in tissue invasion-dependent pathology.},
  keywords = {{AFRIQUE}},
  booktitle = {},
  journal = {e{L}ife},
  volume = {5},
  numero = {},
  pages = {e17716 [17 p.]},
  ISSN = {2050-084{X}},
  year = {2016},
  DOI = {10.7554/e{L}ife.17716},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068311},
}