Publications des scientifiques de l'IRD

Heigele A., Kmiec D., Regensburger K., Langer S., Peiffer L., Sturzel C. M., Sauter D., Peeters Martine, Pizzato M., Learn G. H., Hahn B. H., Kirchhoff F. (2016). The potency of Nef-mediated SERINC5 antagonism correlates with the prevalence of primate lentiviruses in the wild. Cell Host and Microbe, 20 (3), p. 381-391. ISSN 1931-3128.

Titre du document
The potency of Nef-mediated SERINC5 antagonism correlates with the prevalence of primate lentiviruses in the wild
Année de publication
2016
Type de document
Article référencé dans le Web of Science WOS:000384143100014
Auteurs
Heigele A., Kmiec D., Regensburger K., Langer S., Peiffer L., Sturzel C. M., Sauter D., Peeters Martine, Pizzato M., Learn G. H., Hahn B. H., Kirchhoff F.
Source
Cell Host and Microbe, 2016, 20 (3), p. 381-391 ISSN 1931-3128
The cellular factor serine incorporator 5 (SERINC5) impairs HIV-1 infectivity but is antagonized by the viral Nef protein. We analyzed the anti-SERINC5 activity of Nef proteins across primate lentiviruses and examined whether SERINC5 represents a barrier to cross-species transmissions and/or within-species viral spread. HIV-1, HIV-2, and SIV Nefs counteract human, ape, monkey, and murine SERINC5 orthologs with similar potency. However, HIV-1 Nefs are more active against SERINC5 than HIV-2 Nefs, and chimpanzee SIV (SIVcpz) Nefs are more potent than those of their monkey precursors. Additionally, Nefs of HIV and most SIVs rely on the dileucine motif in the C-terminal loop for anti-SERINC5 activity, while the Nef from colobus SIV (SIVcol) evolved different inhibitory mechanisms. We also found a significant correlation between anti-SERINC5 potency and the SIV prevalence in the respective ape and monkey species. Thus, Nef-mediated SERINC5 antagonism may determine the ability of primate lentiviruses to spread within natural hosts.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052] ; Sciences du monde animal [080]
Description Géographique
AFRIQUE
Localisation
Fonds IRD [F B010068190]
Identifiant IRD
fdi:010068190
Contact