%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Heigele, A.
%A Kmiec, D.
%A Regensburger, K.
%A Langer, S.
%A Peiffer, L.
%A Sturzel, C. M.
%A Sauter, D.
%A Peeters, Martine
%A Pizzato, M.
%A Learn, G. H.
%A Hahn, B. H.
%A Kirchhoff, F.
%T The potency of Nef-mediated SERINC5 antagonism correlates with the prevalence of primate lentiviruses in the wild
%D 2016
%L fdi:010068190
%G ENG
%J Cell Host and Microbe
%@ 1931-3128
%K AFRIQUE
%M ISI:000384143100014
%N 3
%P 381-391
%R 10.1016/j.chom.2016.08.004
%U https://www.documentation.ird.fr/hor/fdi:010068190
%> https://www.documentation.ird.fr/intranet/publi/2016/10/010068190.pdf
%V 20
%W Horizon (IRD)
%X The cellular factor serine incorporator 5 (SERINC5) impairs HIV-1 infectivity but is antagonized by the viral Nef protein. We analyzed the anti-SERINC5 activity of Nef proteins across primate lentiviruses and examined whether SERINC5 represents a barrier to cross-species transmissions and/or within-species viral spread. HIV-1, HIV-2, and SIV Nefs counteract human, ape, monkey, and murine SERINC5 orthologs with similar potency. However, HIV-1 Nefs are more active against SERINC5 than HIV-2 Nefs, and chimpanzee SIV (SIVcpz) Nefs are more potent than those of their monkey precursors. Additionally, Nefs of HIV and most SIVs rely on the dileucine motif in the C-terminal loop for anti-SERINC5 activity, while the Nef from colobus SIV (SIVcol) evolved different inhibitory mechanisms. We also found a significant correlation between anti-SERINC5 potency and the SIV prevalence in the respective ape and monkey species. Thus, Nef-mediated SERINC5 antagonism may determine the ability of primate lentiviruses to spread within natural hosts.
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