El-Demerdash A., Moriou C., Martin M. T., Rodrigues-Stien A. D., Petek Sylvain, Demoy-Schneider M., Hall K., Hooper J. N. A., Debitus Cécile, Al-Mourabit A. (2016). Cytotoxic guanidine alkaloids from a French Polynesian Monanchora n. sp. sponge. Journal of Natural Products, 79 (8), p. 1929-1937. ISSN 0163-3864.
Titre du document
Cytotoxic guanidine alkaloids from a French Polynesian Monanchora n. sp. sponge
El-Demerdash A., Moriou C., Martin M. T., Rodrigues-Stien A. D., Petek Sylvain, Demoy-Schneider M., Hall K., Hooper J. N. A., Debitus Cécile, Al-Mourabit A.
Source
Journal of Natural Products, 2016,
79 (8), p. 1929-1937 ISSN 0163-3864
Four bicyclic and three pentacyclic guanidine alkaloids (1-7) were isolated from a French Polynesian Monanchora n. sp. sponge, along with the known alkaloids monalidine A (8), enantiomers 9-11 of known natural product crambescins, and the known crambescidins 12-15. Structures were assigned by spectroscopic data interpretation. The relative and absolute configurations of the alkaloids were established by analysis of H-1 NMR and NOESY spectra and by circular dichroism analysis. The new norcrambescidic acid (7) corresponds to interesting biosynthetic variation within the pentacyclic core. All compounds exhibited antiproliferative and cytotoxic efficacy against KB, HCT116, HL60, MRCS, and B16F10 cancer cells, with IC50 values ranging from 4 nM to 10 mu M.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Substances naturelles [035]
