@article{fdi:010067772,
  title = {{C}ytotoxic guanidine alkaloids from a {F}rench {P}olynesian {M}onanchora n. sp. sponge},
  author = {{E}l-{D}emerdash, {A}. and {M}oriou, {C}. and {M}artin, {M}. {T}. and {R}odrigues-{S}tien, {A}. {D}. and {P}etek, {S}ylvain and {D}emoy-{S}chneider, {M}. and {H}all, {K}. and {H}ooper, {J}. {N}. {A}. and {D}ebitus, {C}{\'e}cile and {A}l-{M}ourabit, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{F}our bicyclic and three pentacyclic guanidine alkaloids (1-7) were isolated from a {F}rench {P}olynesian {M}onanchora n. sp. sponge, along with the known alkaloids monalidine {A} (8), enantiomers 9-11 of known natural product crambescins, and the known crambescidins 12-15. {S}tructures were assigned by spectroscopic data interpretation. {T}he relative and absolute configurations of the alkaloids were established by analysis of {H}-1 {NMR} and {NOESY} spectra and by circular dichroism analysis. {T}he new norcrambescidic acid (7) corresponds to interesting biosynthetic variation within the pentacyclic core. {A}ll compounds exhibited antiproliferative and cytotoxic efficacy against {KB}, {HCT}116, {HL}60, {MRCS}, and {B}16{F}10 cancer cells, with {IC}50 values ranging from 4 n{M} to 10 mu {M}.},
  keywords = {{POLYNESIE} {FRANCAISE}},
  booktitle = {},
  journal = {{J}ournal of {N}atural {P}roducts},
  volume = {79},
  numero = {8},
  pages = {1929--1937},
  ISSN = {0163-3864},
  year = {2016},
  DOI = {10.1021/acs.jnatprod.6b00168},
  URL = {https://www.documentation.ird.fr/hor/fdi:010067772},
}