Villabona-Arenas C. J., Domyeum J., Mouacha Fatima, Butel Christelle, Delaporte Eric, Peeters Martine, Mpoudi-Ngole E., Aghokeng Fobang Avelin. (2015). HIV-1 group O infection in Cameroon from 2006 to 2013 : prevalence, genetic diversity, evolution and public health challenges. Infection Genetics and Evolution, 36, p. 210-216. ISSN 1567-1348.
Titre du document
HIV-1 group O infection in Cameroon from 2006 to 2013 : prevalence, genetic diversity, evolution and public health challenges
Année de publication
2015
Auteurs
Villabona-Arenas C. J., Domyeum J., Mouacha Fatima, Butel Christelle, Delaporte Eric, Peeters Martine, Mpoudi-Ngole E., Aghokeng Fobang Avelin
Source
Infection Genetics and Evolution, 2015,
36, p. 210-216 ISSN 1567-1348
The human immunodeficiency virus, HIV, is characterized by a tremendously high genetic diversity, leading to the currently known circulating HIV types, groups, subtypes, and recombinant forms. HIV-1 group O is one of the most diverse forms of HIV-1 and has been so far related to Cameroon or individuals originating from Cameroon. In this study, we investigated in Cameroon, the evolution of this viral group from 2006 to 2013, in terms of prevalence, genetic diversity and public health implications. Our results confirmed the predominance of HIV-1 group M (98.5%), a very low prevalence (<0.02%) for HIV-1 group N and P, and HIV-2 in this country. HIV-1 group O was found at around 0.6% (95% confidence interval: 0.4-0.8%), indicating that the frequency of this virus in Cameroon has remained stable over the last decades. However, we found an extensive high genetic diversity within this HIV-1 group, that resulted from previous steady increase on the effective number of HIV-1 group O infections through time, and the current distribution of the circulating viral strains still does not allow classification as subtypes. The frequency of dual infections with HIV-1 group M and group O was 0.8% (95% confidence interval: 0.6-1.0%), but we found no recombinant forms in co-infected patients. Natural resistance to integrase inhibitors was not identified, although we found several mutations considered as natural polymorphisms. Our study shows that infections with HIV-1 group O can be adequately managed in countries where the virus circulates, but this complex virus still represents a challenge for diagnostics and monitoring strategies.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
CAMEROUN
Localisation
Fonds IRD [F B010066065]
Identifiant IRD
fdi:010066065
