@article{fdi:010066065,
  title = {{HIV}-1 group {O} infection in {C}ameroon from 2006 to 2013 : prevalence, genetic diversity, evolution and public health challenges},
  author = {{V}illabona-{A}renas, {C}. {J}. and {D}omyeum, {J}. and {M}ouacha, {F}atima and {B}utel, {C}hristelle and {D}elaporte, {E}ric and {P}eeters, {M}artine and {M}poudi-{N}gole, {E}. and {A}ghokeng {F}obang, {A}velin},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he human immunodeficiency virus, {HIV}, is characterized by a tremendously high genetic diversity, leading to the currently known circulating {HIV} types, groups, subtypes, and recombinant forms. {HIV}-1 group {O} is one of the most diverse forms of {HIV}-1 and has been so far related to {C}ameroon or individuals originating from {C}ameroon. {I}n this study, we investigated in {C}ameroon, the evolution of this viral group from 2006 to 2013, in terms of prevalence, genetic diversity and public health implications. {O}ur results confirmed the predominance of {HIV}-1 group {M} (98.5%), a very low prevalence (<0.02%) for {HIV}-1 group {N} and {P}, and {HIV}-2 in this country. {HIV}-1 group {O} was found at around 0.6% (95% confidence interval: 0.4-0.8%), indicating that the frequency of this virus in {C}ameroon has remained stable over the last decades. {H}owever, we found an extensive high genetic diversity within this {HIV}-1 group, that resulted from previous steady increase on the effective number of {HIV}-1 group {O} infections through time, and the current distribution of the circulating viral strains still does not allow classification as subtypes. {T}he frequency of dual infections with {HIV}-1 group {M} and group {O} was 0.8% (95% confidence interval: 0.6-1.0%), but we found no recombinant forms in co-infected patients. {N}atural resistance to integrase inhibitors was not identified, although we found several mutations considered as natural polymorphisms. {O}ur study shows that infections with {HIV}-1 group {O} can be adequately managed in countries where the virus circulates, but this complex virus still represents a challenge for diagnostics and monitoring strategies.},
  keywords = {{HIV}-1 group {O} ; {C}ameroon ; {P}revalence ; {G}enetic diversity ; {D}ual infections ; {R}esistance ; {CAMEROUN}},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {36},
  numero = {},
  pages = {210--216},
  ISSN = {1567-1348},
  year = {2015},
  DOI = {10.1016/j.meegid.2015.09.006},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066065},
}