Publications des scientifiques de l'IRD

Faria N. R., Rambaut A., Suchard M. A., Baele G., Bedford T., Ward M. J., Tatem A. J., Sousa J. D., Arinaminpathy N., Pepin J., Posada D., Peeters Martine, Pybus O. G., Lemey P. (2014). The early spread and epidemic ignition of HIV-1 in human populations. Science, 346 (6205), p. 56-61. ISSN 0036-8075.

Titre du document
The early spread and epidemic ignition of HIV-1 in human populations
Année de publication
2014
Type de document
Article référencé dans le Web of Science WOS:000342446900048
Auteurs
Faria N. R., Rambaut A., Suchard M. A., Baele G., Bedford T., Ward M. J., Tatem A. J., Sousa J. D., Arinaminpathy N., Pepin J., Posada D., Peeters Martine, Pybus O. G., Lemey P.
Source
Science, 2014, 346 (6205), p. 56-61 ISSN 0036-8075
Thirty years after the discovery of HIV-1, the early transmission, dissemination, and establishment of the virus in human populations remain unclear. Using statistical approaches applied to HIV-1 sequence data from central Africa, we show that from the 1920s Kinshasa (in what is now the Democratic Republic of Congo) was the focus of early transmission and the source of pre-1960 pandemic viruses elsewhere. Location and dating estimates were validated using the earliest HIV-1 archival sample, also from Kinshasa. The epidemic histories of HIV-1 group M and nonpandemic group O were similar until similar to 1960, after which group M underwent an epidemiological transition and outpaced regional population growth. Our results reconstruct the early dynamics of HIV-1 and emphasize the role of social changes and transport networks in the establishment of this virus in human populations.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
AFRIQUE CENTRALE ; REPUBLIQUE DEMOCRATIQUE DU CONGO
Localisation
Fonds IRD [F B010062575]
Identifiant IRD
fdi:010062575
Contact