Coffeng L. E., Fobi G., Ozoh G., Bissek A. C., Nlatte B. O., Enyong P., Olinga J. M. O., Zoure H. G. M., Habbema J. D. F., Stolk W. A., de Vlas S. J., Boussinesq Michel, Noma M. (2012). Concurrence of dermatological and ophthalmological morbidity in onchocerciasis. Transactions of the Royal Society of Tropical Medicine and Hygiene, 106 (4), p. 243-251. ISSN 0035-9203.
Titre du document
Concurrence of dermatological and ophthalmological morbidity in onchocerciasis
Année de publication
2012
Auteurs
Coffeng L. E., Fobi G., Ozoh G., Bissek A. C., Nlatte B. O., Enyong P., Olinga J. M. O., Zoure H. G. M., Habbema J. D. F., Stolk W. A., de Vlas S. J., Boussinesq Michel, Noma M.
Source
Transactions of the Royal Society of Tropical Medicine and Hygiene, 2012,
106 (4), p. 243-251 ISSN 0035-9203
Prevalence of skin and eye disorders in African onchocerciasis (river blindness) is well documented. However, less is known about their joint occurrence. Information on concurrence may improve our understanding of disease pathogenesis and is required to estimate the disease burden of onchocerciasis. We analysed data from 765 individuals from forest villages in the Kumba and Ngambe Health districts, Cameroon. These data were collected in 1998, as baseline data for the evaluation of the African Programme for Onchocerciasis Control. Concurrence of symptoms was assessed using logistic regression. Onchocerciasis was highly endemic in the study population (63% nodule prevalence among males aged >= 20). Considerable overall prevalences of onchocercal visual impairment (low vision or blindness: 4%), troublesome itch (15%), reactive skin disease (19%), and skin depigmentation (25%) were observed. The association between onchocercal visual impairment and skin depigmentation (OR 9.0, 95% CI 3.9-20.8) was partly explained by age and exposure to infection (OR 3.0, 95% CI 1.2-7.7). The association between troublesome itch and reactive skin disease was hardly affected by adjustment (adjusted OR 6.9, 95% CI 4.2-11.1). Concluding, there is significant concurrence of morbidities within onchocerciasis. Our results suggest a possible role of host characteristics in the pathogenesis of depigmentation and visual impairment. Further, we propose a method to deal with concurrence when estimating the burden of disease.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010055800]
Identifiant IRD
fdi:010055800
