Kato L., de Oliveira C. M. A., Faria E. O., Ribeiro L. C., Carvalho B. G., da Silva C. C., Schuquel I. T. A., Santin S. M. O., Nakamura C. V., Britta E. A., Miranda N., Iglesias A. H., Delprete Piero. (2012). Antiprotozoal alkaloids from Psychotria prunifolia (Kunth) Steyerm. Journal of the Brazilian Chemical Society, 23 (2), p. 355-360. ISSN 0103-5053.
Titre du document
Antiprotozoal alkaloids from Psychotria prunifolia (Kunth) Steyerm
Année de publication
2012
Auteurs
Kato L., de Oliveira C. M. A., Faria E. O., Ribeiro L. C., Carvalho B. G., da Silva C. C., Schuquel I. T. A., Santin S. M. O., Nakamura C. V., Britta E. A., Miranda N., Iglesias A. H., Delprete Piero
Source
Journal of the Brazilian Chemical Society, 2012,
23 (2), p. 355-360 ISSN 0103-5053
The continuity of the phytochemical study of crude extracts of P. prunifolia's roots and branches led to the isolation of five indole-beta-carboline alkaloids. Among them, the 10-hydroxy-iso-deppeaninol and N-oxide-10-hydroxy-antirhine derivatives are described here for the first time. The structures were achieved through 1D and 2D NMR, IR and HRMS analyses. The branches and roots crude extracts and the alkaloids 14-oxoprunifoleine and strictosamide showed selective activity against L. amazonensis, with IC50 values of 16.0 and 40.7 mu g per mL, respectively.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
;
Sciences du monde végétal [076]
Localisation
Fonds IRD [F B010055739]
Identifiant IRD
fdi:010055739
