@article{fdi:010055739, title = {{A}ntiprotozoal alkaloids from {P}sychotria prunifolia ({K}unth) {S}teyerm}, author = {{K}ato, {L}. and de {O}liveira, {C}. {M}. {A}. and {F}aria, {E}. {O}. and {R}ibeiro, {L}. {C}. and {C}arvalho, {B}. {G}. and da {S}ilva, {C}. {C}. and {S}chuquel, {I}. {T}. {A}. and {S}antin, {S}. {M}. {O}. and {N}akamura, {C}. {V}. and {B}ritta, {E}. {A}. and {M}iranda, {N}. and {I}glesias, {A}. {H}. and {D}elprete, {P}iero}, editor = {}, language = {{ENG}}, abstract = {{T}he continuity of the phytochemical study of crude extracts of {P}. prunifolia's roots and branches led to the isolation of five indole-beta-carboline alkaloids. {A}mong them, the 10-hydroxy-iso-deppeaninol and {N}-oxide-10-hydroxy-antirhine derivatives are described here for the first time. {T}he structures were achieved through 1{D} and 2{D} {NMR}, {IR} and {HRMS} analyses. {T}he branches and roots crude extracts and the alkaloids 14-oxoprunifoleine and strictosamide showed selective activity against {L}. amazonensis, with {IC}50 values of 16.0 and 40.7 mu g per m{L}, respectively.}, keywords = {beta-carboline alkaloids ; antiprotozoal ; {T}rypanosoma ; {L}eishmania ; {P}sychotria prunifolia ; {R}ubiaceae}, booktitle = {}, journal = {{J}ournal of the {B}razilian {C}hemical {S}ociety}, volume = {23}, numero = {2}, pages = {355--360}, ISSN = {0103-5053}, year = {2012}, URL = {https://www.documentation.ird.fr/hor/fdi:010055739}, }