Yalcindag E., Elguero Eric, Arnathau C., Durand P., Akiana J., Anderson T.J., Aubouy Agnès, Balloux F., Besnard P., Bogreau H., Carnevale Pierre, D'Alessandro U., Fontenille Didier, Gamboa D., Jombart T., Le Mire J., Leroy Eric, Maestre A., Mayxay M., Menard D., Musset L., Newton P. N., Nkoghe D., Noya O., Ollomo B., Rogier C., Veron V., Wide A., Zakeri S., Carme B., Legrand E., Chevillon C., Ayala F.J., Renaud F., Prugnolle F. (2012). Multiple independent introductions of Plasmodium falciparum in South America. Proceedings of the National Academy of Sciences of the United States of America, 109 (2), p. 511-516. ISSN 0027-8424.
Titre du document
Multiple independent introductions of Plasmodium falciparum in South America
Année de publication
2012
Auteurs
Yalcindag E., Elguero Eric, Arnathau C., Durand P., Akiana J., Anderson T.J., Aubouy Agnès, Balloux F., Besnard P., Bogreau H., Carnevale Pierre, D'Alessandro U., Fontenille Didier, Gamboa D., Jombart T., Le Mire J., Leroy Eric, Maestre A., Mayxay M., Menard D., Musset L., Newton P. N., Nkoghe D., Noya O., Ollomo B., Rogier C., Veron V., Wide A., Zakeri S., Carme B., Legrand E., Chevillon C., Ayala F.J., Renaud F., Prugnolle F.
Source
Proceedings of the National Academy of Sciences of the United States of America, 2012,
109 (2), p. 511-516 ISSN 0027-8424
The origin of Plasmodium falciparum in South America is controversial. Some studies suggest a recent introduction during the European colonizations and the transatlantic slave trade. Other evidence-archeological and genetic-suggests a much older origin. We collected and analyzed P. falciparum isolates from different regions of the world, encompassing the distribution range of the parasite, including populations from sub-Saharan Africa, the Middle East, Southeast Asia, and South America. Analyses of microsatellite and SNP polymorphisms show that the populations of P. falciparum in South America are subdivided in two main genetic clusters (northern and southern). Phylogenetic analyses, as well as Approximate Bayesian Computation methods suggest independent introductions of the two clusters from African sources. Our estimates of divergence time between the South American populations and their likely sources favor a likely introduction from Africa during the transatlantic slave trade.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
AMERIQUE LATINE ; AFRIQUE
Localisation
Fonds IRD [F B010054311]
Identifiant IRD
fdi:010054311
