Magistrado P. A., Minja D., Doritchamou J., Tuikue Ndam Nicaise, John D., Schmiegelow C., Massougbodji A., Dahlback M., Ditlev S. B., Pinto V. V., Resende M., Lusingu J., Theander T. G., Salanti A., Nielsen M. A. (2011). High efficacy of anti DBL4 epsilon-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women. Vaccine, 29 (3), p. 437-443. ISSN 0264-410X.
Titre du document
High efficacy of anti DBL4 epsilon-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women
Année de publication
2011
Auteurs
Magistrado P. A., Minja D., Doritchamou J., Tuikue Ndam Nicaise, John D., Schmiegelow C., Massougbodji A., Dahlback M., Ditlev S. B., Pinto V. V., Resende M., Lusingu J., Theander T. G., Salanti A., Nielsen M. A.
Source
Vaccine, 2011,
29 (3), p. 437-443 ISSN 0264-410X
Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before the first pregnancy. Antibodies against domain DBL4 epsilon from VAR2CSA has been shown to inhibit adhesion of laboratory isolates to the placental receptor chondroitin sulfate A. In this study, the binding inhibitory efficacy of IgG elicited by two different DBL4 epsilon recombinant proteins was tested on a panel of fresh clinical isolates from pregnant women living in Benin and Tanzania. The most promising recombinant protein elicited antibodies with similar efficacy as pooled plasma from immune multi-gravid African women.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010053064]
Identifiant IRD
fdi:010053064
