Couto Fernandez J. C., Eyer Silva W. A., Guimaraes M. L., Chequer Fernandez S. L., Grinsztejn B., Delaporte E., Peeters M., Morgado M. G. (2006). Phylogenetic analysis of Brazilian HIV type 1 subtype D strains: Tracing the origin of this subtype in Brazil. Aids Research and Human Retroviruses, 22 (2), p. 207-211.
Titre du document
Phylogenetic analysis of Brazilian HIV type 1 subtype D strains: Tracing the origin of this subtype in Brazil
Couto Fernandez J. C., Eyer Silva W. A., Guimaraes M. L., Chequer Fernandez S. L., Grinsztejn B., Delaporte E., Peeters M., Morgado M. G.
Source
Aids Research and Human Retroviruses, 2006,
22 (2), p. 207-211
HIV-1 Subtype D occurs mainly in East and Central African countries, especially Uganda, where the prevalence of HIV-1 infection is among the highest in the world. We present the phylogenetic analysis of one nonau-tochthonous and four autochthonous (including a near full-length genome) Brazilian HIV-1 subtype D strains identified in Rio de Janeiro State, where subtypes B, F1, and BF1 recombinants predominate. Phylogenetic inferences using maximum likelihood were applied on a near-full length genome and on concatenated gag, protease, reverse transcriptase, integrase, C2V3/env, gp41, and nef segments. Sequences from an Angolan immigrant showed close genetic similarity with a strain described in Finland, from an HIV patient of African origin, whereas all four autochthonous Brazilian sequences clustered with South African strains, where subtype D occurs only in isolated cases. Our results suggest the successful introduction and circulation in Brazil of closely related HIV-1 subtype D strains, possibly of South African origin.
