%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Couto Fernandez, J. C.
%A Eyer Silva, W. A.
%A Guimaraes, M. L.
%A Chequer Fernandez, S. L.
%A Grinsztejn, B.
%A Delaporte, E.
%A Peeters, M.
%A Morgado, M. G.
%T Phylogenetic analysis of Brazilian HIV type 1 subtype D strains: Tracing the origin of this subtype in Brazil
%D 2006
%L fdi:010052291
%G ENG
%J Aids Research and Human Retroviruses
%M CC:0002354722-0014
%N 2
%P 207-211
%R 10.1089/aid.2006.22.207
%U https://www.documentation.ird.fr/hor/fdi:010052291
%> https://www.documentation.ird.fr/intranet/publi/depot/2011-07-27/010052291.pdf
%V 22
%W Horizon (IRD)
%X HIV-1 Subtype D occurs mainly in East and Central African countries, especially Uganda, where the prevalence of HIV-1 infection is among the highest in the world. We present the phylogenetic analysis of one nonau-tochthonous and four autochthonous (including a near full-length genome) Brazilian HIV-1 subtype D strains identified in Rio de Janeiro State, where subtypes B, F1, and BF1 recombinants predominate. Phylogenetic inferences using maximum likelihood were applied on a near-full length genome and on concatenated gag, protease, reverse transcriptase, integrase, C2V3/env, gp41, and nef segments. Sequences from an Angolan immigrant showed close genetic similarity with a strain described in Finland, from an HIV patient of African origin, whereas all four autochthonous Brazilian sequences clustered with South African strains, where subtype D occurs only in isolated cases. Our results suggest the successful introduction and circulation in Brazil of closely related HIV-1 subtype D strains, possibly of South African origin.