Publications des scientifiques de l'IRD

Vidal Nicole, Mulanga Claire, Bazepeo S.E., Lepira F., Delaporte Eric, Peeters Martine. (2006). Identification and molecular characterization of subsubtype A4 in Central Africa. Aids Research and Human Retroviruses, 22 (2), p. 182-187.

Titre du document
Identification and molecular characterization of subsubtype A4 in Central Africa
Année de publication
2006
Type de document
Article référencé dans le Web of Science WOS:000235472200010
Auteurs
Vidal Nicole, Mulanga Claire, Bazepeo S.E., Lepira F., Delaporte Eric, Peeters Martine
Source
Aids Research and Human Retroviruses, 2006, 22 (2), p. 182-187
Phylogenetic analysis on partial env sequences of HIV-1-positive samples obtained from sentinel population groups in HIV serosurveillance studies in 1997 and 2002 in the Democratic Republic of Congo (DRC) revealed a high genetic diversity in the number of cocirculating subtypes/CRFs as well as intrasubtype diversity. A cluster of three strains that formed a distinct and well-separated group within the subtype A radiation was observed. To determine a more precise structure of these viruses, the full-length genomes were sequenced. Phylogenetic tree and bootscan analysis showed that all three newly characterized viruses formed a new nonrecombinant lineage that was more closely related to subtype A. The SUDI (Subtype Distance) program showed that the distances of the newly derived HIV-1 sequences to subtype A references fell in the range of distances previously characterized for subsubtypes. According to current nomenclature rules, we have thus designated this new lineage as subsubtype A4. Analysis of viral sequences from other African countries suggests that the A4 strains seem restricted to DRC where they already circulated at the onset of the HIV/AIDS epidemic.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
CENTRAFRIQUE
Localisation
Fonds IRD [F B010052120]
Identifiant IRD
fdi:010052120
Contact