Publications des scientifiques de l'IRD

Vanhecke C., Guevart E., Ezzedine K., Receveur M. C., Jamonneau Vincent, Bucheton Bruno, Camara M., Vincendeau P., Malvy D. (2010). La trypanosomose humaine africaine en faciès épidémiologique de mangrove. Présentation, déterminants et prise en charge dans le contexte de la Guinée (2005 à 2007) = Human African Trypanosomiasis in mangrove epidemiologic area. Presentation, diagnosis and treatment in Guinea, 2005-2007. Pathologie Biologie, 58 (1), p. 110-116. ISSN 0369-8114.

Titre du document
La trypanosomose humaine africaine en faciès épidémiologique de mangrove. Présentation, déterminants et prise en charge dans le contexte de la Guinée (2005 à 2007) = Human African Trypanosomiasis in mangrove epidemiologic area. Presentation, diagnosis and treatment in Guinea, 2005-2007
Année de publication
2010
Type de document
Article référencé dans le Web of Science WOS:000275483500023
Auteurs
Vanhecke C., Guevart E., Ezzedine K., Receveur M. C., Jamonneau Vincent, Bucheton Bruno, Camara M., Vincendeau P., Malvy D.
Source
Pathologie Biologie, 2010, 58 (1), p. 110-116 ISSN 0369-8114
Gambiense human African trypanosomiasis is still assumed to be endemic in many part of West Africa, particularly in Guinea coastal area with mangrove swamp. Diagnosis is usually made during active medical screening or by passive initiative. Objectives. - To describe clinical and epidemiological characteristics of Gambiense human African trypanosomiasis in the coastal area of Guinea. Methods. - Exhaustive and retrospective analysis of all patients attending the trypanosomiasis center in the coastal area of Guinea between January 2005 and December 2007 with a diagnosis of human African trypanosomiasis. Results. - A total of 196 patients were recruited for the study. out of them, 55 % of the 73 patients diagnosed during active screening were classified stage I (haemolymphatic stage) or early stage 2 (meningoencephalitic stage). Contrarily, 115 of the 120 diagnosed by passive procedure were classified late stage 2, which features more specific signs and neurological symptoms, and leads to coma and death. More than 90 % of all cases presented cervical lymph nodes with identification of trypanosome on direct examination of fluid puncture. Less than one third of the patients were reexamined three months later. Discussion. - In the coastal area of Guinea with mangrove swamp, direct examination of lymph node fluid puncture seems to be the most contributive test for the diagnosis of human African trypanosomiasis. Hence, associating clinical examination of cervical lymph nodes area and direct examination of fluid puncture may allow an early diagnosis of Gambiense human African trypanosomiasis and favor the implementation of efficient therapeutic strategies.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010049366]
Identifiant IRD
fdi:010049366
Contact