Corrales Rosa Milagros, Sereno Denis, Mathieu-Daudé Françoise. (2010). Deciphering the Leishmania exoproteome : what we know and what we can learn. Fems Immunology and Medical Microbiology, 58 (1), p. 27-38. ISSN 0928-8244.
Titre du document
Deciphering the Leishmania exoproteome : what we know and what we can learn
Corrales Rosa Milagros, Sereno Denis, Mathieu-Daudé Françoise
Source
Fems Immunology and Medical Microbiology, 2010,
58 (1), p. 27-38 ISSN 0928-8244
Parasitic protozoa of the genus Leishmania are the causative agents of leishmaniasis. Survival and transmission of these parasites in their different hosts require membrane-bound or extracellular factors to interact with and modify their host environments. Over the last decade, several approaches have been applied to study all the extracellular proteins exported by an organism at a particular time or stage in its life cycle and under defined conditions, collectively termed the secretome or the exoproteome. In this review, we focus on emerging data shedding light on the secretion mechanisms involved in the production of the Leishmania exoproteome. We also describe other methodologies currently available that could be used to analyse the Leishmania exoproteome. Understanding the complexity of the Leishmania exoproteome is a key component to elucidating the mechanisms used by these parasites for exporting proteins to the extracellular space during its life cycle. Given the importance of extracellular factors, a detailed knowledge of the Leishmania exoproteome may provide novel targets for rational drug design and/or a source of antigens for vaccine development.
