@article{fdi:010049216, title = {{D}eciphering the {L}eishmania exoproteome : what we know and what we can learn}, author = {{C}orrales, {R}osa {M}ilagros and {S}ereno, {D}enis and {M}athieu-{D}aud{\'e}, {F}ran{\c{c}}oise}, editor = {}, language = {{ENG}}, abstract = {{P}arasitic protozoa of the genus {L}eishmania are the causative agents of leishmaniasis. {S}urvival and transmission of these parasites in their different hosts require membrane-bound or extracellular factors to interact with and modify their host environments. {O}ver the last decade, several approaches have been applied to study all the extracellular proteins exported by an organism at a particular time or stage in its life cycle and under defined conditions, collectively termed the secretome or the exoproteome. {I}n this review, we focus on emerging data shedding light on the secretion mechanisms involved in the production of the {L}eishmania exoproteome. {W}e also describe other methodologies currently available that could be used to analyse the {L}eishmania exoproteome. {U}nderstanding the complexity of the {L}eishmania exoproteome is a key component to elucidating the mechanisms used by these parasites for exporting proteins to the extracellular space during its life cycle. {G}iven the importance of extracellular factors, a detailed knowledge of the {L}eishmania exoproteome may provide novel targets for rational drug design and/or a source of antigens for vaccine development.}, keywords = {secretion mechanisms ; {L}eishmania secretome ; secreted virulence factors}, booktitle = {}, journal = {{F}ems {I}mmunology and {M}edical {M}icrobiology}, volume = {58}, numero = {1}, pages = {27--38}, ISSN = {0928-8244}, year = {2010}, DOI = {10.1111/j.1574-695{X}.2009.00608.x}, URL = {https://www.documentation.ird.fr/hor/fdi:010049216}, }