@article{fdi:010049216,
  title = {{D}eciphering the {L}eishmania exoproteome : what we know and what we can learn},
  author = {{C}orrales, {R}osa {M}ilagros and {S}ereno, {D}enis and {M}athieu-{D}aud{\'e}, {F}ran{\c{c}}oise},
  editor = {},
  language = {{ENG}},
  abstract = {{P}arasitic protozoa of the genus {L}eishmania are the causative agents of leishmaniasis. {S}urvival and transmission of these parasites in their different hosts require membrane-bound or extracellular factors to interact with and modify their host environments. {O}ver the last decade, several approaches have been applied to study all the extracellular proteins exported by an organism at a particular time or stage in its life cycle and under defined conditions, collectively termed the secretome or the exoproteome. {I}n this review, we focus on emerging data shedding light on the secretion mechanisms involved in the production of the {L}eishmania exoproteome. {W}e also describe other methodologies currently available that could be used to analyse the {L}eishmania exoproteome. {U}nderstanding the complexity of the {L}eishmania exoproteome is a key component to elucidating the mechanisms used by these parasites for exporting proteins to the extracellular space during its life cycle. {G}iven the importance of extracellular factors, a detailed knowledge of the {L}eishmania exoproteome may provide novel targets for rational drug design and/or a source of antigens for vaccine development.},
  keywords = {secretion mechanisms ; {L}eishmania secretome ; secreted virulence factors},
  booktitle = {},
  journal = {{F}ems {I}mmunology and {M}edical {M}icrobiology},
  volume = {58},
  numero = {1},
  pages = {27--38},
  ISSN = {0928-8244},
  year = {2010},
  DOI = {10.1111/j.1574-695{X}.2009.00608.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010049216},
}